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Unilateral denervation of the rat urinary bladder and reinnervation: a predominance for ipsilateral changes

Ekstrom, J; Malmberg, Lars LU and Oberg, S (1986) In Acta Physiologica Scandinavica 127(2). p.223-231
Abstract
Unilateral removal of the pelvic ganglion affected the bladder-half on the denervated side more profoundly than that on the non-denervated side. At an early stage (3-7 days) the former was heavier, had a lower choline acetyltransferase activity, developed less tension to nerve stimulation and, in course of time, became more sensitized to methacholine in vitro than the latter. At a late stage (30-60 days) the nerve-evoked contractile responses on the denervated side had increased, which was almost wholly attributed to the atropine-sensitive part of the contraction, but the recovery was not complete. On the non-denervated side the nerve-evoked responses were not significantly changed. It was calculated that in the normally innervated... (More)
Unilateral removal of the pelvic ganglion affected the bladder-half on the denervated side more profoundly than that on the non-denervated side. At an early stage (3-7 days) the former was heavier, had a lower choline acetyltransferase activity, developed less tension to nerve stimulation and, in course of time, became more sensitized to methacholine in vitro than the latter. At a late stage (30-60 days) the nerve-evoked contractile responses on the denervated side had increased, which was almost wholly attributed to the atropine-sensitive part of the contraction, but the recovery was not complete. On the non-denervated side the nerve-evoked responses were not significantly changed. It was calculated that in the normally innervated bladders 25-30% of the cholinergic nerves of each half were of contralateral origin. The figure was lower (18%) for the nerves mediating the atropine-resistant response. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
127
issue
2
pages
223 - 231
publisher
Wiley-Blackwell
external identifiers
  • pmid:3524118
  • scopus:0022591702
ISSN
0001-6772
language
English
LU publication?
yes
id
a1ddb064-ad61-4752-bf53-d87ca4ce9999 (old id 1103617)
date added to LUP
2008-08-11 09:53:39
date last changed
2017-02-22 11:44:32
@article{a1ddb064-ad61-4752-bf53-d87ca4ce9999,
  abstract     = {Unilateral removal of the pelvic ganglion affected the bladder-half on the denervated side more profoundly than that on the non-denervated side. At an early stage (3-7 days) the former was heavier, had a lower choline acetyltransferase activity, developed less tension to nerve stimulation and, in course of time, became more sensitized to methacholine in vitro than the latter. At a late stage (30-60 days) the nerve-evoked contractile responses on the denervated side had increased, which was almost wholly attributed to the atropine-sensitive part of the contraction, but the recovery was not complete. On the non-denervated side the nerve-evoked responses were not significantly changed. It was calculated that in the normally innervated bladders 25-30% of the cholinergic nerves of each half were of contralateral origin. The figure was lower (18%) for the nerves mediating the atropine-resistant response.},
  author       = {Ekstrom, J and Malmberg, Lars and Oberg, S},
  issn         = {0001-6772},
  language     = {eng},
  number       = {2},
  pages        = {223--231},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {Unilateral denervation of the rat urinary bladder and reinnervation: a predominance for ipsilateral changes},
  volume       = {127},
  year         = {1986},
}