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Indices of mineral metabolism in relation to blood pressure in a sample of a healthy population

Hvarfner, Andreas LU ; Ljunghall, S; Mörlin, C; Wide, L and Bergstrom, R (1986) In Acta Medica Scandinavica 219(5). p.461-468
Abstract
Indices of mineral metabolism in blood and urine were analysed in relation to blood pressure in 97 healthy subjects aged 16-82 years. In a multivariate analysis, after allowing for the effects of sex, body mass index (BMI) and age, there was an inverse relationship between plasma level of ionized calcium and mean blood pressure (MBP) (beta = -50.0 mmHg/mmol/l P-ionized calcium, p = 0.0005). In univariate analyses MBP also showed statistically significant inverse relationships with plasma ionized calcium, serum phosphate and renal threshold concentration of phosphate; positive relationships to MBP were found for fasting urinary excretion of calcium and cyclic adenosine monophosphate. However, when examined multivariately, only the relation... (More)
Indices of mineral metabolism in blood and urine were analysed in relation to blood pressure in 97 healthy subjects aged 16-82 years. In a multivariate analysis, after allowing for the effects of sex, body mass index (BMI) and age, there was an inverse relationship between plasma level of ionized calcium and mean blood pressure (MBP) (beta = -50.0 mmHg/mmol/l P-ionized calcium, p = 0.0005). In univariate analyses MBP also showed statistically significant inverse relationships with plasma ionized calcium, serum phosphate and renal threshold concentration of phosphate; positive relationships to MBP were found for fasting urinary excretion of calcium and cyclic adenosine monophosphate. However, when examined multivariately, only the relation between MBP and plasma ionized calcium persisted. This study supports previous findings of an inverse relationship between blood pressure and serum ionized calcium and extends the observations to the physiological range. It is further evident from this study that BMI and age should be taken into account in analyses of the relationship between blood pressure and mineral metabolism. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Acta Medica Scandinavica
volume
219
issue
5
pages
461 - 468
publisher
Norstedts
external identifiers
  • pmid:3017054
  • scopus:0022536167
ISSN
0001-6101
language
English
LU publication?
yes
id
be5ef83d-3585-45fd-ae65-e0a06ddefed0 (old id 1103683)
date added to LUP
2008-08-11 10:55:20
date last changed
2017-08-06 04:41:29
@article{be5ef83d-3585-45fd-ae65-e0a06ddefed0,
  abstract     = {Indices of mineral metabolism in blood and urine were analysed in relation to blood pressure in 97 healthy subjects aged 16-82 years. In a multivariate analysis, after allowing for the effects of sex, body mass index (BMI) and age, there was an inverse relationship between plasma level of ionized calcium and mean blood pressure (MBP) (beta = -50.0 mmHg/mmol/l P-ionized calcium, p = 0.0005). In univariate analyses MBP also showed statistically significant inverse relationships with plasma ionized calcium, serum phosphate and renal threshold concentration of phosphate; positive relationships to MBP were found for fasting urinary excretion of calcium and cyclic adenosine monophosphate. However, when examined multivariately, only the relation between MBP and plasma ionized calcium persisted. This study supports previous findings of an inverse relationship between blood pressure and serum ionized calcium and extends the observations to the physiological range. It is further evident from this study that BMI and age should be taken into account in analyses of the relationship between blood pressure and mineral metabolism.},
  author       = {Hvarfner, Andreas and Ljunghall, S and Mörlin, C and Wide, L and Bergstrom, R},
  issn         = {0001-6101},
  language     = {eng},
  number       = {5},
  pages        = {461--468},
  publisher    = {Norstedts},
  series       = {Acta Medica Scandinavica},
  title        = {Indices of mineral metabolism in relation to blood pressure in a sample of a healthy population},
  volume       = {219},
  year         = {1986},
}