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Post-transfusion hepatitis type non-A, non-B in southern Sweden: occurrence and clinical significance

Widell, Anders LU ; Sundstrom, Gunnar; Hansson, Bengt-Göran LU ; Fex, Göran; Moestrup, Torkil and Nordenfelt, Erik (1987) In Scandinavian Journal of Infectious Diseases 19(6). p.603-610
Abstract
Two prospective studies of the occurrence and clinical significance of post-transfusion hepatitis non-A, non-B were performed in Malmo, Sweden. In both studies, patients of a broad clinical spectrum were followed up 6 and 12 weeks after transfusion. In a 7 week study from 1983, hepatitis non-A, non-B occurred in 9/173 transfused patients (5.2%) versus 1/203 untransfused controls (0.5%) (p less than 0.01). In a 6 month study from 1984-85, the incidence of hepatitis non-A, non-B had declined to 2.4% (18/739 transfused patients). The mean number of transfused units was about 5 in both studies and most patients had subclinical disease. Despite similar transfusion volumes to patients above or below 70 years of age, hepatitis non-A, non-B was... (More)
Two prospective studies of the occurrence and clinical significance of post-transfusion hepatitis non-A, non-B were performed in Malmo, Sweden. In both studies, patients of a broad clinical spectrum were followed up 6 and 12 weeks after transfusion. In a 7 week study from 1983, hepatitis non-A, non-B occurred in 9/173 transfused patients (5.2%) versus 1/203 untransfused controls (0.5%) (p less than 0.01). In a 6 month study from 1984-85, the incidence of hepatitis non-A, non-B had declined to 2.4% (18/739 transfused patients). The mean number of transfused units was about 5 in both studies and most patients had subclinical disease. Despite similar transfusion volumes to patients above or below 70 years of age, hepatitis non-A, non-B was predominantly seen among patients less than 70 years. In the 1984-85 study, hepatitis non-A, non-B incidence was 1.2% in recipients greater than or equal to 70 years, 3.4% in recipients less than 70 years and 4.5% in recipients less than 40 years. One year after the initial hepatitis non-A, non-B episode, 4/18 patients (22%) had biochemical signs of chronic hepatitis. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
19
issue
6
pages
603 - 610
publisher
Informa Healthcare
external identifiers
  • pmid:3126546
  • scopus:0023583773
ISSN
1651-1980
DOI
10.3109/00365548709117193
language
English
LU publication?
yes
id
43c667dc-6ba9-497c-a5bf-e6b4bd00c94e (old id 1103741)
date added to LUP
2008-08-08 12:03:43
date last changed
2017-01-01 06:51:50
@article{43c667dc-6ba9-497c-a5bf-e6b4bd00c94e,
  abstract     = {Two prospective studies of the occurrence and clinical significance of post-transfusion hepatitis non-A, non-B were performed in Malmo, Sweden. In both studies, patients of a broad clinical spectrum were followed up 6 and 12 weeks after transfusion. In a 7 week study from 1983, hepatitis non-A, non-B occurred in 9/173 transfused patients (5.2%) versus 1/203 untransfused controls (0.5%) (p less than 0.01). In a 6 month study from 1984-85, the incidence of hepatitis non-A, non-B had declined to 2.4% (18/739 transfused patients). The mean number of transfused units was about 5 in both studies and most patients had subclinical disease. Despite similar transfusion volumes to patients above or below 70 years of age, hepatitis non-A, non-B was predominantly seen among patients less than 70 years. In the 1984-85 study, hepatitis non-A, non-B incidence was 1.2% in recipients greater than or equal to 70 years, 3.4% in recipients less than 70 years and 4.5% in recipients less than 40 years. One year after the initial hepatitis non-A, non-B episode, 4/18 patients (22%) had biochemical signs of chronic hepatitis.},
  author       = {Widell, Anders and Sundstrom, Gunnar and Hansson, Bengt-Göran and Fex, Göran and Moestrup, Torkil and Nordenfelt, Erik},
  issn         = {1651-1980},
  language     = {eng},
  number       = {6},
  pages        = {603--610},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Post-transfusion hepatitis type non-A, non-B in southern Sweden: occurrence and clinical significance},
  url          = {http://dx.doi.org/10.3109/00365548709117193},
  volume       = {19},
  year         = {1987},
}