Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site
(1987) In International Archives of Allergy and Applied Immunology 83(1). p.88-91- Abstract
- Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab')2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab')2 of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103796
- author
- Schröder, A K ; Gharavi, A E ; Steinitz, M ; Johansson, Hugo LU and Christensen, P
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Archives of Allergy and Applied Immunology
- volume
- 83
- issue
- 1
- pages
- 88 - 91
- publisher
- Karger
- external identifiers
-
- pmid:3570527
- scopus:0023277861
- ISSN
- 0020-5915
- language
- English
- LU publication?
- yes
- id
- 82cc5c31-03b5-4bb0-839b-2c96a7fc08c1 (old id 1103796)
- date added to LUP
- 2016-04-01 15:52:39
- date last changed
- 2021-01-03 07:50:39
@article{82cc5c31-03b5-4bb0-839b-2c96a7fc08c1, abstract = {{Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab')2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab')2 of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.}}, author = {{Schröder, A K and Gharavi, A E and Steinitz, M and Johansson, Hugo and Christensen, P}}, issn = {{0020-5915}}, language = {{eng}}, number = {{1}}, pages = {{88--91}}, publisher = {{Karger}}, series = {{International Archives of Allergy and Applied Immunology}}, title = {{Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site}}, volume = {{83}}, year = {{1987}}, }