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Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site

Schröder, A K; Gharavi, A E; Steinitz, M; Johansson, Hugo LU and Christensen, P (1987) In International Archives of Allergy and Applied Immunology 83(1). p.88-91
Abstract
Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab')2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab')2 of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Archives of Allergy and Applied Immunology
volume
83
issue
1
pages
88 - 91
publisher
Karger
external identifiers
  • pmid:3570527
  • scopus:0023277861
ISSN
0020-5915
language
English
LU publication?
yes
id
82cc5c31-03b5-4bb0-839b-2c96a7fc08c1 (old id 1103796)
date added to LUP
2008-08-08 12:58:31
date last changed
2017-01-01 06:49:16
@article{82cc5c31-03b5-4bb0-839b-2c96a7fc08c1,
  abstract     = {Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab')2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab')2 of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.},
  author       = {Schröder, A K and Gharavi, A E and Steinitz, M and Johansson, Hugo and Christensen, P},
  issn         = {0020-5915},
  language     = {eng},
  number       = {1},
  pages        = {88--91},
  publisher    = {Karger},
  series       = {International Archives of Allergy and Applied Immunology},
  title        = {Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site},
  volume       = {83},
  year         = {1987},
}