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Lewis blood group antigens in urine sediments from patients with urinary bladder carcinoma

Mårtensson, S; Brodin, T; Chester, Alan LU ; Colleen, Stig LU and Lundblad, A (1987) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 21(3). p.197-201
Abstract
Urine sediments from 20 patients with urinary bladder carcinoma, and from 11 healthy individuals were investigated for their content of Lea and Leb active glycolipids. The investigation was restricted to blood group phenotype Le (a-b+). All individuals exhibited both Lea- and Leb-active glycolipids. In healthy individuals the ratio Lea/Leb was less than 1 in 10 out of 11 cases, whereas in patients with bladder cancer the ratio Lea/Leb was greater than 1 in 11 out of 20 cases. No correlation between the Lea/Leb ratio on the one hand and tumour grade or stage on the other hand could be shown. The results indicate one possible explanation for the loss of ABH antigens in bladder cancer and also demonstrate the potential of detailed biochemical... (More)
Urine sediments from 20 patients with urinary bladder carcinoma, and from 11 healthy individuals were investigated for their content of Lea and Leb active glycolipids. The investigation was restricted to blood group phenotype Le (a-b+). All individuals exhibited both Lea- and Leb-active glycolipids. In healthy individuals the ratio Lea/Leb was less than 1 in 10 out of 11 cases, whereas in patients with bladder cancer the ratio Lea/Leb was greater than 1 in 11 out of 20 cases. No correlation between the Lea/Leb ratio on the one hand and tumour grade or stage on the other hand could be shown. The results indicate one possible explanation for the loss of ABH antigens in bladder cancer and also demonstrate the potential of detailed biochemical investigations on exfoliated material in urine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
21
issue
3
pages
197 - 201
publisher
Taylor & Francis
external identifiers
  • pmid:3433020
  • scopus:0023242496
ISSN
0036-5599
language
English
LU publication?
yes
id
8e8116c3-53bc-45a7-b205-836a0862fa4c (old id 1103832)
date added to LUP
2008-08-08 13:29:07
date last changed
2017-02-22 11:44:29
@article{8e8116c3-53bc-45a7-b205-836a0862fa4c,
  abstract     = {Urine sediments from 20 patients with urinary bladder carcinoma, and from 11 healthy individuals were investigated for their content of Lea and Leb active glycolipids. The investigation was restricted to blood group phenotype Le (a-b+). All individuals exhibited both Lea- and Leb-active glycolipids. In healthy individuals the ratio Lea/Leb was less than 1 in 10 out of 11 cases, whereas in patients with bladder cancer the ratio Lea/Leb was greater than 1 in 11 out of 20 cases. No correlation between the Lea/Leb ratio on the one hand and tumour grade or stage on the other hand could be shown. The results indicate one possible explanation for the loss of ABH antigens in bladder cancer and also demonstrate the potential of detailed biochemical investigations on exfoliated material in urine.},
  author       = {Mårtensson, S and Brodin, T and Chester, Alan and Colleen, Stig and Lundblad, A},
  issn         = {0036-5599},
  language     = {eng},
  number       = {3},
  pages        = {197--201},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Lewis blood group antigens in urine sediments from patients with urinary bladder carcinoma},
  volume       = {21},
  year         = {1987},
}