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Platelet aggregation in type I diabetics with and without proliferative retinopathy

Agardh, Carl-David LU ; Agardh, Elisabet LU and Bauer, B (1987) In Acta Ophthalmologica 65(3). p.358-362
Abstract
The cause of retinopathy in diabetes mellitus is unknown. Among factors suggested to be involved in the development of retinopathy is altered platelet function. In the present study, platelet aggregation was measured in vitro after stimulation with adenosine diphosphate (ADP) and collagen in patients with and without proliferative retinopathy. The results show that patients with proliferative retinopathy have an increased platelet aggregation in vitro after stimulation with collagen and ADP. However, the increased platelet aggregation was also found to be correlated to the duration of diabetes. Thus, the present study does not support the opinion that abnormal platelet function can be regarded as a primary cause of diabetic retinopathy.... (More)
The cause of retinopathy in diabetes mellitus is unknown. Among factors suggested to be involved in the development of retinopathy is altered platelet function. In the present study, platelet aggregation was measured in vitro after stimulation with adenosine diphosphate (ADP) and collagen in patients with and without proliferative retinopathy. The results show that patients with proliferative retinopathy have an increased platelet aggregation in vitro after stimulation with collagen and ADP. However, the increased platelet aggregation was also found to be correlated to the duration of diabetes. Thus, the present study does not support the opinion that abnormal platelet function can be regarded as a primary cause of diabetic retinopathy. Increased platelet aggregation seems to be coupled to the duration of diabetes and to still unknown factors developing with prolonged duration of the disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Ophthalmologica
volume
65
issue
3
pages
358 - 362
publisher
Wiley-Blackwell
external identifiers
  • pmid:3618162
  • scopus:0023238975
ISSN
0001-639X
language
English
LU publication?
yes
id
f8d6246d-3d17-4669-8dd3-9042ad6a6fd0 (old id 1103859)
date added to LUP
2008-08-08 14:51:28
date last changed
2017-01-01 07:18:09
@article{f8d6246d-3d17-4669-8dd3-9042ad6a6fd0,
  abstract     = {The cause of retinopathy in diabetes mellitus is unknown. Among factors suggested to be involved in the development of retinopathy is altered platelet function. In the present study, platelet aggregation was measured in vitro after stimulation with adenosine diphosphate (ADP) and collagen in patients with and without proliferative retinopathy. The results show that patients with proliferative retinopathy have an increased platelet aggregation in vitro after stimulation with collagen and ADP. However, the increased platelet aggregation was also found to be correlated to the duration of diabetes. Thus, the present study does not support the opinion that abnormal platelet function can be regarded as a primary cause of diabetic retinopathy. Increased platelet aggregation seems to be coupled to the duration of diabetes and to still unknown factors developing with prolonged duration of the disease.},
  author       = {Agardh, Carl-David and Agardh, Elisabet and Bauer, B},
  issn         = {0001-639X},
  language     = {eng},
  number       = {3},
  pages        = {358--362},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Platelet aggregation in type I diabetics with and without proliferative retinopathy},
  volume       = {65},
  year         = {1987},
}