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Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder

Ekstrom, J; Malmberg, Lars LU and Wallin, A (1987) In Pharmacology and Toxicology 60(2). p.86-89
Abstract
The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized... (More)
The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacology and Toxicology
volume
60
issue
2
pages
86 - 89
publisher
Wiley-Blackwell
external identifiers
  • pmid:3554208
  • scopus:0023147699
ISSN
1600-0773
language
English
LU publication?
yes
id
93f9dc55-16a5-4820-b63a-7b288eb5c3e4 (old id 1103894)
date added to LUP
2008-08-08 15:53:49
date last changed
2017-02-22 11:44:12
@article{93f9dc55-16a5-4820-b63a-7b288eb5c3e4,
  abstract     = {The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves.},
  author       = {Ekstrom, J and Malmberg, Lars and Wallin, A},
  issn         = {1600-0773},
  language     = {eng},
  number       = {2},
  pages        = {86--89},
  publisher    = {Wiley-Blackwell},
  series       = {Pharmacology and Toxicology},
  title        = {Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder},
  volume       = {60},
  year         = {1987},
}