Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder
(1987) In Pharmacology and Toxicology 60(2). p.86-89- Abstract
- The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized... (More)
- The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103894
- author
- Ekstrom, J ; Malmberg, Lars LU and Wallin, A
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pharmacology and Toxicology
- volume
- 60
- issue
- 2
- pages
- 86 - 89
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3554208
- scopus:0023147699
- ISSN
- 1600-0773
- language
- English
- LU publication?
- yes
- id
- 93f9dc55-16a5-4820-b63a-7b288eb5c3e4 (old id 1103894)
- date added to LUP
- 2016-04-01 12:15:35
- date last changed
- 2021-01-03 04:49:41
@article{93f9dc55-16a5-4820-b63a-7b288eb5c3e4,
abstract = {{The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves.}},
author = {{Ekstrom, J and Malmberg, Lars and Wallin, A}},
issn = {{1600-0773}},
language = {{eng}},
number = {{2}},
pages = {{86--89}},
publisher = {{Wiley-Blackwell}},
series = {{Pharmacology and Toxicology}},
title = {{Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder}},
volume = {{60}},
year = {{1987}},
}