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Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis?

Lexell, Jan LU ; Downham, David and Sjöstrom, Michael (1987) In Acta Neuropathologica 75(2). p.109-115
Abstract
The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and... (More)
The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Nerve degeneration, Muscular atrophy, Muscle denervation, Histocytochemistry, Aging
in
Acta Neuropathologica
volume
75
issue
2
pages
109 - 115
publisher
Springer
external identifiers
  • pmid:3324621
  • scopus:0023502323
ISSN
1432-0533
DOI
10.1007/BF00687070
language
English
LU publication?
no
id
d2d018fe-2253-438d-b62e-8d337761d220 (old id 1103950)
date added to LUP
2008-08-08 16:56:43
date last changed
2017-01-01 07:26:05
@article{d2d018fe-2253-438d-b62e-8d337761d220,
  abstract     = {The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development.},
  author       = {Lexell, Jan and Downham, David and Sjöstrom, Michael},
  issn         = {1432-0533},
  keyword      = {Nerve degeneration,Muscular atrophy,Muscle denervation,Histocytochemistry,Aging},
  language     = {eng},
  number       = {2},
  pages        = {109--115},
  publisher    = {Springer},
  series       = {Acta Neuropathologica},
  title        = {Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis?},
  url          = {http://dx.doi.org/10.1007/BF00687070},
  volume       = {75},
  year         = {1987},
}