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5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

Hansson, Elisabeth ; Simonsson, Per LU and Alling, Christer LU (1987) In Neuropharmacology 26(9). p.1377-1382
Abstract
5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain stem, hippocampus, striatum, second messenger, astroglial primary culture, cerebral cortex, diacylglycerol, inositol trisphosphate, 5-HT2-receptor
in
Neuropharmacology
volume
26
issue
9
pages
1377 - 1382
publisher
Elsevier
external identifiers
  • pmid:2823165
  • scopus:0023264893
ISSN
1873-7064
DOI
10.1016/0028-3908(87)90102-X
language
English
LU publication?
yes
id
006d404f-5bf1-4edf-8394-f170bbaa1e01 (old id 1103953)
date added to LUP
2016-04-01 11:39:55
date last changed
2021-01-31 06:30:58
@article{006d404f-5bf1-4edf-8394-f170bbaa1e01,
  abstract     = {{5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.}},
  author       = {{Hansson, Elisabeth and Simonsson, Per and Alling, Christer}},
  issn         = {{1873-7064}},
  keywords     = {{brain stem; hippocampus; striatum; second messenger; astroglial primary culture; cerebral cortex; diacylglycerol; inositol trisphosphate; 5-HT2-receptor}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1377--1382}},
  publisher    = {{Elsevier}},
  series       = {{Neuropharmacology}},
  title        = {{5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain}},
  url          = {{http://dx.doi.org/10.1016/0028-3908(87)90102-X}},
  doi          = {{10.1016/0028-3908(87)90102-X}},
  volume       = {{26}},
  year         = {{1987}},
}