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5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

Hansson, Elisabeth; Simonsson, Per LU and Alling, Christer LU (1987) In Neuropharmacology 26(9). p.1377-1382
Abstract
5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain stem, hippocampus, striatum, second messenger, astroglial primary culture, cerebral cortex, diacylglycerol, inositol trisphosphate, 5-HT2-receptor
in
Neuropharmacology
volume
26
issue
9
pages
1377 - 1382
publisher
Elsevier
external identifiers
  • pmid:2823165
  • scopus:0023264893
ISSN
1873-7064
DOI
10.1016/0028-3908(87)90102-X
language
English
LU publication?
yes
id
006d404f-5bf1-4edf-8394-f170bbaa1e01 (old id 1103953)
date added to LUP
2008-08-08 16:59:20
date last changed
2017-08-06 03:31:42
@article{006d404f-5bf1-4edf-8394-f170bbaa1e01,
  abstract     = {5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.},
  author       = {Hansson, Elisabeth and Simonsson, Per and Alling, Christer},
  issn         = {1873-7064},
  keyword      = {brain stem,hippocampus,striatum,second messenger,astroglial primary culture,cerebral cortex,diacylglycerol,inositol trisphosphate,5-HT2-receptor},
  language     = {eng},
  number       = {9},
  pages        = {1377--1382},
  publisher    = {Elsevier},
  series       = {Neuropharmacology},
  title        = {5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain},
  url          = {http://dx.doi.org/10.1016/0028-3908(87)90102-X},
  volume       = {26},
  year         = {1987},
}