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Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment

Persson, E; Nordenstrom, J; Hagenfeldt, L and Nilsson-Ehle, Peter LU (1987) In Thrombosis Research 46(5). p.697-704
Abstract
The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity... (More)
The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity but has a negligible effect on plasma lipolytic activity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Heparin, hepatic lipase, lipoprotein lipase, low molecular weight heparin
in
Thrombosis Research
volume
46
issue
5
pages
697 - 704
publisher
Elsevier
external identifiers
  • pmid:3629543
  • scopus:0023263094
ISSN
1879-2472
DOI
10.1016/0049-3848(87)90271-4
language
English
LU publication?
yes
id
b01737c9-c00c-46ab-a4d3-d5a82b393193 (old id 1103958)
date added to LUP
2008-08-08 17:03:16
date last changed
2017-01-01 04:45:52
@article{b01737c9-c00c-46ab-a4d3-d5a82b393193,
  abstract     = {The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity but has a negligible effect on plasma lipolytic activity.},
  author       = {Persson, E and Nordenstrom, J and Hagenfeldt, L and Nilsson-Ehle, Peter},
  issn         = {1879-2472},
  keyword      = {Heparin,hepatic lipase,lipoprotein lipase,low molecular weight heparin},
  language     = {eng},
  number       = {5},
  pages        = {697--704},
  publisher    = {Elsevier},
  series       = {Thrombosis Research},
  title        = {Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment},
  url          = {http://dx.doi.org/10.1016/0049-3848(87)90271-4},
  volume       = {46},
  year         = {1987},
}