Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment
(1987) In Thrombosis Research 46(5). p.697-704- Abstract
- The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity... (More)
- The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity but has a negligible effect on plasma lipolytic activity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103958
- author
- Persson, E ; Nordenstrom, J ; Hagenfeldt, L and Nilsson-Ehle, Peter LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Heparin, hepatic lipase, lipoprotein lipase, low molecular weight heparin
- in
- Thrombosis Research
- volume
- 46
- issue
- 5
- pages
- 697 - 704
- publisher
- Elsevier
- external identifiers
-
- pmid:3629543
- scopus:0023263094
- ISSN
- 1879-2472
- DOI
- 10.1016/0049-3848(87)90271-4
- language
- English
- LU publication?
- yes
- id
- b01737c9-c00c-46ab-a4d3-d5a82b393193 (old id 1103958)
- date added to LUP
- 2016-04-01 12:01:26
- date last changed
- 2025-04-04 15:11:29
@article{b01737c9-c00c-46ab-a4d3-d5a82b393193,
abstract = {{The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity but has a negligible effect on plasma lipolytic activity.}},
author = {{Persson, E and Nordenstrom, J and Hagenfeldt, L and Nilsson-Ehle, Peter}},
issn = {{1879-2472}},
keywords = {{Heparin; hepatic lipase; lipoprotein lipase; low molecular weight heparin}},
language = {{eng}},
number = {{5}},
pages = {{697--704}},
publisher = {{Elsevier}},
series = {{Thrombosis Research}},
title = {{Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment}},
url = {{http://dx.doi.org/10.1016/0049-3848(87)90271-4}},
doi = {{10.1016/0049-3848(87)90271-4}},
volume = {{46}},
year = {{1987}},
}