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Early post-traumatic changes in hemodynamics and pulmonary ventilation in alcohol-pretreated pigs

Blomqvist, S; Thörne, Johan LU ; Elmer, O; Jönsson, Bo-Anders LU ; Strand, Sven-Erik LU and Lindahl, S G (1987) In Journal of Trauma 27(1). p.40-44
Abstract
Time relations among trauma, pulmonary and systemic circulation, and lung function were studied in pigs. Eleven animals (b.w. 25-30 kg) were investigated under balanced anesthesia. Ventilation was mechanically controlled. Hemodynamics, pulmonary ventilation, and gas exchange were serially recorded. Seven animals were pretreated with 40% ethanol in saline and four with saline only. Ninety minutes after the ingestion of alcohol or saline, the animals were subjected to a standardized soft-tissue trauma. Cardiac output decreased significantly 2 minutes after trauma and remained low in both groups throughout the observation period of 30 minutes. Pulmonary vascular resistance was significantly increased in the alcohol-pretreated group but was... (More)
Time relations among trauma, pulmonary and systemic circulation, and lung function were studied in pigs. Eleven animals (b.w. 25-30 kg) were investigated under balanced anesthesia. Ventilation was mechanically controlled. Hemodynamics, pulmonary ventilation, and gas exchange were serially recorded. Seven animals were pretreated with 40% ethanol in saline and four with saline only. Ninety minutes after the ingestion of alcohol or saline, the animals were subjected to a standardized soft-tissue trauma. Cardiac output decreased significantly 2 minutes after trauma and remained low in both groups throughout the observation period of 30 minutes. Pulmonary vascular resistance was significantly increased in the alcohol-pretreated group but was virtually unchanged in the control animals. Systemic vascular resistance was similarly reduced in the two groups. Total compliance was somewhat lower in alcohol-pretreated animals and 10 minutes after the trauma arterial oxygen tension was significantly lower in the alcohol group than in control animals. Carbon dioxide elimination was reduced after trauma in both groups. It is concluded that pulmonary vascular response increased and that total pulmonary compliance is somewhat decreased shortly after trauma in the alcohol group while gas exchange is almost unchanged. The results indicate a negative interaction between alcohol and trauma (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Trauma
volume
27
issue
1
pages
40 - 44
publisher
Lippincott Williams and Wilkins
external identifiers
  • scopus:0023146772
ISSN
0022-5282
language
English
LU publication?
yes
id
b8726c21-039f-4262-9f48-9a1b8771c355 (old id 1104027)
date added to LUP
2008-08-08 17:54:21
date last changed
2017-01-01 07:23:37
@article{b8726c21-039f-4262-9f48-9a1b8771c355,
  abstract     = {Time relations among trauma, pulmonary and systemic circulation, and lung function were studied in pigs. Eleven animals (b.w. 25-30 kg) were investigated under balanced anesthesia. Ventilation was mechanically controlled. Hemodynamics, pulmonary ventilation, and gas exchange were serially recorded. Seven animals were pretreated with 40% ethanol in saline and four with saline only. Ninety minutes after the ingestion of alcohol or saline, the animals were subjected to a standardized soft-tissue trauma. Cardiac output decreased significantly 2 minutes after trauma and remained low in both groups throughout the observation period of 30 minutes. Pulmonary vascular resistance was significantly increased in the alcohol-pretreated group but was virtually unchanged in the control animals. Systemic vascular resistance was similarly reduced in the two groups. Total compliance was somewhat lower in alcohol-pretreated animals and 10 minutes after the trauma arterial oxygen tension was significantly lower in the alcohol group than in control animals. Carbon dioxide elimination was reduced after trauma in both groups. It is concluded that pulmonary vascular response increased and that total pulmonary compliance is somewhat decreased shortly after trauma in the alcohol group while gas exchange is almost unchanged. The results indicate a negative interaction between alcohol and trauma},
  author       = {Blomqvist, S and Thörne, Johan and Elmer, O and Jönsson, Bo-Anders and Strand, Sven-Erik and Lindahl, S G},
  issn         = {0022-5282},
  language     = {eng},
  number       = {1},
  pages        = {40--44},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Journal of Trauma},
  title        = {Early post-traumatic changes in hemodynamics and pulmonary ventilation in alcohol-pretreated pigs},
  volume       = {27},
  year         = {1987},
}