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Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions

Rubin, Kristofer; Tingström, Anders LU ; Hansson, Göran K; Larsson, Erik; Rönnstrand, Lars LU ; Klareskog, Lars; Claesson-Welsh, Lena; Heldin, Carl-Henrik; Fellström, Bengt and Terracio, Louis (1988) In The Lancet 331(8599). p.1353-1356
Abstract
Expression of B-type receptors for platelet-derived growth factor (PDGF) in frozen sections of blood vessels from tissues affected by abnormal vascular cell proliferation was investigated by immunohistochemical techniques and compared with expression of these receptors in blood vessels of normal tissues. Receptors were not expressed, or expressed at low levels, in vessels of normal tissues. In contrast, a pronounced expression of PDGF B-type receptors was seen on vascular smooth muscle cells in atherosclerotic plaques, rejected kidneys, and chronic synovitis. These observations suggest induction of PDGF B-type receptors on vascular smooth muscle cells in inflamed tissues, which would render such cells responsive to growth stimulation by... (More)
Expression of B-type receptors for platelet-derived growth factor (PDGF) in frozen sections of blood vessels from tissues affected by abnormal vascular cell proliferation was investigated by immunohistochemical techniques and compared with expression of these receptors in blood vessels of normal tissues. Receptors were not expressed, or expressed at low levels, in vessels of normal tissues. In contrast, a pronounced expression of PDGF B-type receptors was seen on vascular smooth muscle cells in atherosclerotic plaques, rejected kidneys, and chronic synovitis. These observations suggest induction of PDGF B-type receptors on vascular smooth muscle cells in inflamed tissues, which would render such cells responsive to growth stimulation by PDGF released from captured platelets, or produced locally (eg, by inflammatory cells or smooth muscle cells). Autocrine or paracrine stimulation of cell growth caused by the effect of PDGF on cells with induced receptors may be important in the formation of the proliferative lesions found in atherosclerosis and in certain forms of chronic inflammation. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
331
issue
8599
pages
1353 - 1356
publisher
Elsevier Limited
external identifiers
  • pmid:2898041
  • scopus:0023908814
ISSN
1474-547X
DOI
10.1016/S0140-6736(88)92177-0
language
English
LU publication?
no
id
e8d77b96-2ab7-4178-a273-c270c7c1147b (old id 1104044)
date added to LUP
2008-08-07 14:12:18
date last changed
2017-08-06 03:33:40
@article{e8d77b96-2ab7-4178-a273-c270c7c1147b,
  abstract     = {Expression of B-type receptors for platelet-derived growth factor (PDGF) in frozen sections of blood vessels from tissues affected by abnormal vascular cell proliferation was investigated by immunohistochemical techniques and compared with expression of these receptors in blood vessels of normal tissues. Receptors were not expressed, or expressed at low levels, in vessels of normal tissues. In contrast, a pronounced expression of PDGF B-type receptors was seen on vascular smooth muscle cells in atherosclerotic plaques, rejected kidneys, and chronic synovitis. These observations suggest induction of PDGF B-type receptors on vascular smooth muscle cells in inflamed tissues, which would render such cells responsive to growth stimulation by PDGF released from captured platelets, or produced locally (eg, by inflammatory cells or smooth muscle cells). Autocrine or paracrine stimulation of cell growth caused by the effect of PDGF on cells with induced receptors may be important in the formation of the proliferative lesions found in atherosclerosis and in certain forms of chronic inflammation.},
  author       = {Rubin, Kristofer and Tingström, Anders and Hansson, Göran K and Larsson, Erik and Rönnstrand, Lars and Klareskog, Lars and Claesson-Welsh, Lena and Heldin, Carl-Henrik and Fellström, Bengt and Terracio, Louis},
  issn         = {1474-547X},
  language     = {eng},
  number       = {8599},
  pages        = {1353--1356},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions},
  url          = {http://dx.doi.org/10.1016/S0140-6736(88)92177-0},
  volume       = {331},
  year         = {1988},
}