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Relation between donor transaminase and recipient hepatitis non-A, non-B in Sweden

Widell, Anders LU ; Sundstrom, G; Hansson, B G; Fex, G; Moestrup, T and Nordenfelt, E (1988) In Vox Sanguinis 54(3). p.154-159
Abstract
The relation between donor alanine aminotransferase (ALT) and recipient post-transfusion hepatitis (PTH) non-A, non-B was studied in patients tested before and 6 and 12 weeks after transfusion. The minimum ALT criterion for PTH was 105 IU/l (greater than 2.5 times the upper normal of 42 IU/l). In 8.8% of donors, ALT was greater than 42 IU/l, and in 2.3% ALT was greater than 63 IU/l, i.e., 1.5 times elevated. PTH non-A, non-B occurred in 14 of 742 recipients. The PTH incidence increased when donor ALT was above 63 IU/l (1.5 vs. 5.6%; p less than 0.05). However, if the confounding factor of volume variations was compensated for, elevated donor ALT and PTH were only statistically linked among recipients less than 70 years (p less than 0.02;... (More)
The relation between donor alanine aminotransferase (ALT) and recipient post-transfusion hepatitis (PTH) non-A, non-B was studied in patients tested before and 6 and 12 weeks after transfusion. The minimum ALT criterion for PTH was 105 IU/l (greater than 2.5 times the upper normal of 42 IU/l). In 8.8% of donors, ALT was greater than 42 IU/l, and in 2.3% ALT was greater than 63 IU/l, i.e., 1.5 times elevated. PTH non-A, non-B occurred in 14 of 742 recipients. The PTH incidence increased when donor ALT was above 63 IU/l (1.5 vs. 5.6%; p less than 0.05). However, if the confounding factor of volume variations was compensated for, elevated donor ALT and PTH were only statistically linked among recipients less than 70 years (p less than 0.02; Mantel-Haenszel test). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vox Sanguinis
volume
54
issue
3
pages
154 - 159
publisher
Wiley-Blackwell
external identifiers
  • pmid:3130727
  • scopus:0023889230
ISSN
1423-0410
language
English
LU publication?
yes
id
e6ca4884-be45-4823-af80-6fcc0863cbb5 (old id 1104062)
date added to LUP
2008-08-07 10:02:50
date last changed
2017-08-06 04:25:54
@article{e6ca4884-be45-4823-af80-6fcc0863cbb5,
  abstract     = {The relation between donor alanine aminotransferase (ALT) and recipient post-transfusion hepatitis (PTH) non-A, non-B was studied in patients tested before and 6 and 12 weeks after transfusion. The minimum ALT criterion for PTH was 105 IU/l (greater than 2.5 times the upper normal of 42 IU/l). In 8.8% of donors, ALT was greater than 42 IU/l, and in 2.3% ALT was greater than 63 IU/l, i.e., 1.5 times elevated. PTH non-A, non-B occurred in 14 of 742 recipients. The PTH incidence increased when donor ALT was above 63 IU/l (1.5 vs. 5.6%; p less than 0.05). However, if the confounding factor of volume variations was compensated for, elevated donor ALT and PTH were only statistically linked among recipients less than 70 years (p less than 0.02; Mantel-Haenszel test).},
  author       = {Widell, Anders and Sundstrom, G and Hansson, B G and Fex, G and Moestrup, T and Nordenfelt, E},
  issn         = {1423-0410},
  language     = {eng},
  number       = {3},
  pages        = {154--159},
  publisher    = {Wiley-Blackwell},
  series       = {Vox Sanguinis},
  title        = {Relation between donor transaminase and recipient hepatitis non-A, non-B in Sweden},
  volume       = {54},
  year         = {1988},
}