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Inhibition of herpes simplex virus growth caused by preparations of animal immunoglobulins is not dependent on Fc-Fc receptor interactions

Johansson, Hugo LU and Kjellen, Lars (1988) In Intervirology 29(6). p.334-338
Abstract
Rabbit, horse, rat, and chicken immunoglobulin G (IgG); rabbit, horse, and goat IgG Fc fragments; rabbit and chicken F(ab')2 fragments, and rat and chicken gamma globulins, in concentrations of 5 and 10 mg/ml, were able to reduce virus production 10- to 10,000-fold when incubated with herpes simplex virus type 1 (HSV-1)-infected GMK AH1 cells. When the ability of the purified IgGs and gamma globulins to interact with the HSV-induced Fc receptor on infected GMK cells was tested, only rabbit IgG and IgG Fc fragments from rabbit and goat were reactive. Thus, there was no correlation between the ability to interact with the HSV Fc receptor and the ability to inhibit viral growth. The ability of IgGs and gamma globulins to reduce HSV production... (More)
Rabbit, horse, rat, and chicken immunoglobulin G (IgG); rabbit, horse, and goat IgG Fc fragments; rabbit and chicken F(ab')2 fragments, and rat and chicken gamma globulins, in concentrations of 5 and 10 mg/ml, were able to reduce virus production 10- to 10,000-fold when incubated with herpes simplex virus type 1 (HSV-1)-infected GMK AH1 cells. When the ability of the purified IgGs and gamma globulins to interact with the HSV-induced Fc receptor on infected GMK cells was tested, only rabbit IgG and IgG Fc fragments from rabbit and goat were reactive. Thus, there was no correlation between the ability to interact with the HSV Fc receptor and the ability to inhibit viral growth. The ability of IgGs and gamma globulins to reduce HSV production is, therefore, not likely to be mediated by the HSV Fc receptor. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Herpes simplex virus, Fc receptors, Immunoglobulins, Viral production
in
Intervirology
volume
29
issue
6
pages
334 - 338
publisher
Karger
external identifiers
  • pmid:2466016
  • scopus:0023774931
ISSN
0300-5526
DOI
10.1159/000150064
language
English
LU publication?
yes
id
45c5d462-d837-4b03-b428-89a114aa879e (old id 1104123)
date added to LUP
2008-08-07 10:52:32
date last changed
2017-01-01 04:24:23
@article{45c5d462-d837-4b03-b428-89a114aa879e,
  abstract     = {Rabbit, horse, rat, and chicken immunoglobulin G (IgG); rabbit, horse, and goat IgG Fc fragments; rabbit and chicken F(ab')2 fragments, and rat and chicken gamma globulins, in concentrations of 5 and 10 mg/ml, were able to reduce virus production 10- to 10,000-fold when incubated with herpes simplex virus type 1 (HSV-1)-infected GMK AH1 cells. When the ability of the purified IgGs and gamma globulins to interact with the HSV-induced Fc receptor on infected GMK cells was tested, only rabbit IgG and IgG Fc fragments from rabbit and goat were reactive. Thus, there was no correlation between the ability to interact with the HSV Fc receptor and the ability to inhibit viral growth. The ability of IgGs and gamma globulins to reduce HSV production is, therefore, not likely to be mediated by the HSV Fc receptor.},
  author       = {Johansson, Hugo and Kjellen, Lars},
  issn         = {0300-5526},
  keyword      = {Herpes simplex virus,Fc receptors,Immunoglobulins,Viral production},
  language     = {eng},
  number       = {6},
  pages        = {334--338},
  publisher    = {Karger},
  series       = {Intervirology},
  title        = {Inhibition of herpes simplex virus growth caused by preparations of animal immunoglobulins is not dependent on Fc-Fc receptor interactions},
  url          = {http://dx.doi.org/10.1159/000150064},
  volume       = {29},
  year         = {1988},
}