Inhibition of herpes simplex virus growth caused by preparations of animal immunoglobulins is not dependent on Fc-Fc receptor interactions
(1988) In Intervirology 29(6). p.334-338- Abstract
- Rabbit, horse, rat, and chicken immunoglobulin G (IgG); rabbit, horse, and goat IgG Fc fragments; rabbit and chicken F(ab')2 fragments, and rat and chicken gamma globulins, in concentrations of 5 and 10 mg/ml, were able to reduce virus production 10- to 10,000-fold when incubated with herpes simplex virus type 1 (HSV-1)-infected GMK AH1 cells. When the ability of the purified IgGs and gamma globulins to interact with the HSV-induced Fc receptor on infected GMK cells was tested, only rabbit IgG and IgG Fc fragments from rabbit and goat were reactive. Thus, there was no correlation between the ability to interact with the HSV Fc receptor and the ability to inhibit viral growth. The ability of IgGs and gamma globulins to reduce HSV production... (More)
- Rabbit, horse, rat, and chicken immunoglobulin G (IgG); rabbit, horse, and goat IgG Fc fragments; rabbit and chicken F(ab')2 fragments, and rat and chicken gamma globulins, in concentrations of 5 and 10 mg/ml, were able to reduce virus production 10- to 10,000-fold when incubated with herpes simplex virus type 1 (HSV-1)-infected GMK AH1 cells. When the ability of the purified IgGs and gamma globulins to interact with the HSV-induced Fc receptor on infected GMK cells was tested, only rabbit IgG and IgG Fc fragments from rabbit and goat were reactive. Thus, there was no correlation between the ability to interact with the HSV Fc receptor and the ability to inhibit viral growth. The ability of IgGs and gamma globulins to reduce HSV production is, therefore, not likely to be mediated by the HSV Fc receptor. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104123
- author
- Johansson, Hugo LU and Kjellen, Lars
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Herpes simplex virus, Fc receptors, Immunoglobulins, Viral production
- in
- Intervirology
- volume
- 29
- issue
- 6
- pages
- 334 - 338
- publisher
- Karger
- external identifiers
-
- pmid:2466016
- scopus:0023774931
- ISSN
- 0300-5526
- DOI
- 10.1159/000150064
- language
- English
- LU publication?
- yes
- id
- 45c5d462-d837-4b03-b428-89a114aa879e (old id 1104123)
- date added to LUP
- 2016-04-01 11:38:58
- date last changed
- 2021-01-03 11:15:34
@article{45c5d462-d837-4b03-b428-89a114aa879e, abstract = {{Rabbit, horse, rat, and chicken immunoglobulin G (IgG); rabbit, horse, and goat IgG Fc fragments; rabbit and chicken F(ab')2 fragments, and rat and chicken gamma globulins, in concentrations of 5 and 10 mg/ml, were able to reduce virus production 10- to 10,000-fold when incubated with herpes simplex virus type 1 (HSV-1)-infected GMK AH1 cells. When the ability of the purified IgGs and gamma globulins to interact with the HSV-induced Fc receptor on infected GMK cells was tested, only rabbit IgG and IgG Fc fragments from rabbit and goat were reactive. Thus, there was no correlation between the ability to interact with the HSV Fc receptor and the ability to inhibit viral growth. The ability of IgGs and gamma globulins to reduce HSV production is, therefore, not likely to be mediated by the HSV Fc receptor.}}, author = {{Johansson, Hugo and Kjellen, Lars}}, issn = {{0300-5526}}, keywords = {{Herpes simplex virus; Fc receptors; Immunoglobulins; Viral production}}, language = {{eng}}, number = {{6}}, pages = {{334--338}}, publisher = {{Karger}}, series = {{Intervirology}}, title = {{Inhibition of herpes simplex virus growth caused by preparations of animal immunoglobulins is not dependent on Fc-Fc receptor interactions}}, url = {{http://dx.doi.org/10.1159/000150064}}, doi = {{10.1159/000150064}}, volume = {{29}}, year = {{1988}}, }