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Oligosaccharides from feces of preterm infants fed on breast milk

Sabharwal, Hemant; Nilsson, Bo; Grönberg, Gunnar; Chester, Alan LU ; Dakour, Jamal; Sjöblad, Sture LU and Lundblad, Arne (1988) In Archives of Biochemistry and Biophysics 265(2). p.390-406
Abstract
Nine neutral and five acidic oligosaccharides were isolated from feces of a preterm (30th postmenstrual week) blood group A nonsecretor infant fed on pooled breast milk. Structural analyses were carried out using sugar and methylation analyses, fast atom bombardment mass spectrometry, and 1H NMR. The acidic oligosaccharides are well-known components of human milk. The neutral oligosaccharides are characteristic of nonsecretor milk. Surprisingly, no secretor gene-dependent oligosaccharides were present in the feces. Another preterm (27th postmenstrual week) blood group A, secretor infant fed on pooled breast milk showed the same fecal oligosaccharide pattern as above during the first week after birth, despite being a secretor individual.... (More)
Nine neutral and five acidic oligosaccharides were isolated from feces of a preterm (30th postmenstrual week) blood group A nonsecretor infant fed on pooled breast milk. Structural analyses were carried out using sugar and methylation analyses, fast atom bombardment mass spectrometry, and 1H NMR. The acidic oligosaccharides are well-known components of human milk. The neutral oligosaccharides are characteristic of nonsecretor milk. Surprisingly, no secretor gene-dependent oligosaccharides were present in the feces. Another preterm (27th postmenstrual week) blood group A, secretor infant fed on pooled breast milk showed the same fecal oligosaccharide pattern as above during the first week after birth, despite being a secretor individual. Also notable was the absence of blood group A-active oligosaccharides in this sample. Another sample of feces collected 8 weeks later from the latter infant contained the expected blood group A-active oligosaccharides. Furthermore, free sialic acid was present at the cost of the sialyl oligosaccharides seen earlier. Thus, infants born prematurely do not show the same degree of development of oligosaccharide metabolism as their more mature counterparts. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Biochemistry and Biophysics
volume
265
issue
2
pages
390 - 406
publisher
Academic Press
external identifiers
  • pmid:3421714
  • scopus:0023722344
ISSN
0003-9861
DOI
10.1016/0003-9861(88)90142-7
language
English
LU publication?
yes
id
00c66ed0-5324-47c7-9ad4-343f188e0fec (old id 1104151)
date added to LUP
2008-08-07 14:02:14
date last changed
2017-07-23 03:37:37
@article{00c66ed0-5324-47c7-9ad4-343f188e0fec,
  abstract     = {Nine neutral and five acidic oligosaccharides were isolated from feces of a preterm (30th postmenstrual week) blood group A nonsecretor infant fed on pooled breast milk. Structural analyses were carried out using sugar and methylation analyses, fast atom bombardment mass spectrometry, and 1H NMR. The acidic oligosaccharides are well-known components of human milk. The neutral oligosaccharides are characteristic of nonsecretor milk. Surprisingly, no secretor gene-dependent oligosaccharides were present in the feces. Another preterm (27th postmenstrual week) blood group A, secretor infant fed on pooled breast milk showed the same fecal oligosaccharide pattern as above during the first week after birth, despite being a secretor individual. Also notable was the absence of blood group A-active oligosaccharides in this sample. Another sample of feces collected 8 weeks later from the latter infant contained the expected blood group A-active oligosaccharides. Furthermore, free sialic acid was present at the cost of the sialyl oligosaccharides seen earlier. Thus, infants born prematurely do not show the same degree of development of oligosaccharide metabolism as their more mature counterparts.},
  author       = {Sabharwal, Hemant and Nilsson, Bo and Grönberg, Gunnar and Chester, Alan and Dakour, Jamal and Sjöblad, Sture and Lundblad, Arne},
  issn         = {0003-9861},
  language     = {eng},
  number       = {2},
  pages        = {390--406},
  publisher    = {Academic Press},
  series       = {Archives of Biochemistry and Biophysics},
  title        = {Oligosaccharides from feces of preterm infants fed on breast milk},
  url          = {http://dx.doi.org/10.1016/0003-9861(88)90142-7},
  volume       = {265},
  year         = {1988},
}