Urinary excretion of a glucose-containing tetrasaccharide. A parameter for increased degradation of glycogen
(1988) In Clinica Chimica Acta 176(1). p.39-48- Abstract
- The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excretion of Glc4 after meals. A carbohydrate-rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a Rhesus monkey resulted in increased excretion of Glc4. When Glc4 itself was injected intravenously in small amounts renal clearance... (More)
- The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excretion of Glc4 after meals. A carbohydrate-rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a Rhesus monkey resulted in increased excretion of Glc4. When Glc4 itself was injected intravenously in small amounts renal clearance was rapid and complete. In contrast, injection of a larger amount resulted in incomplete (approximately 10%) renal clearance, probably due to uptake and metabolism of the oligosaccharide. In patients with glycogen storage diseases, certain malignancies, and pancreatitis, 24 h urinary Glc4 excretion exceeded the normal range. The diagnostic implications of these observations deserve evaluation. The results presented suggest a need for standardization of nutritional status and physical activity when monitoring urinary Glc4 excretion for diagnostic purposes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104159
- author
- Kumlien, Johan ; Chester, Alan LU ; Lindberg, Bo S ; Pizzo, Phillip ; Zopf, David and Lundblad, Arne
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Urinary excretion, Tetrasaccharide, Glycogen metabolism
- in
- Clinica Chimica Acta
- volume
- 176
- issue
- 1
- pages
- 39 - 48
- publisher
- Elsevier
- external identifiers
-
- pmid:3168292
- scopus:0023677099
- ISSN
- 0009-8981
- DOI
- 10.1016/0009-8981(88)90172-6
- language
- English
- LU publication?
- yes
- id
- b8d56af3-89ee-4357-8f62-8e3edf22c890 (old id 1104159)
- date added to LUP
- 2016-04-01 12:00:31
- date last changed
- 2021-08-01 03:22:00
@article{b8d56af3-89ee-4357-8f62-8e3edf22c890,
abstract = {{The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excretion of Glc4 after meals. A carbohydrate-rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a Rhesus monkey resulted in increased excretion of Glc4. When Glc4 itself was injected intravenously in small amounts renal clearance was rapid and complete. In contrast, injection of a larger amount resulted in incomplete (approximately 10%) renal clearance, probably due to uptake and metabolism of the oligosaccharide. In patients with glycogen storage diseases, certain malignancies, and pancreatitis, 24 h urinary Glc4 excretion exceeded the normal range. The diagnostic implications of these observations deserve evaluation. The results presented suggest a need for standardization of nutritional status and physical activity when monitoring urinary Glc4 excretion for diagnostic purposes.}},
author = {{Kumlien, Johan and Chester, Alan and Lindberg, Bo S and Pizzo, Phillip and Zopf, David and Lundblad, Arne}},
issn = {{0009-8981}},
keywords = {{Urinary excretion; Tetrasaccharide; Glycogen metabolism}},
language = {{eng}},
number = {{1}},
pages = {{39--48}},
publisher = {{Elsevier}},
series = {{Clinica Chimica Acta}},
title = {{Urinary excretion of a glucose-containing tetrasaccharide. A parameter for increased degradation of glycogen}},
url = {{http://dx.doi.org/10.1016/0009-8981(88)90172-6}},
doi = {{10.1016/0009-8981(88)90172-6}},
volume = {{176}},
year = {{1988}},
}