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Urinary excretion of a glucose-containing tetrasaccharide. A parameter for increased degradation of glycogen

Kumlien, Johan; Chester, Alan LU ; Lindberg, Bo S; Pizzo, Phillip; Zopf, David and Lundblad, Arne (1988) In Clinica Chimica Acta 176(1). p.39-48
Abstract
The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excretion of Glc4 after meals. A carbohydrate-rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a Rhesus monkey resulted in increased excretion of Glc4. When Glc4 itself was injected intravenously in small amounts renal clearance... (More)
The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excretion of Glc4 after meals. A carbohydrate-rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a Rhesus monkey resulted in increased excretion of Glc4. When Glc4 itself was injected intravenously in small amounts renal clearance was rapid and complete. In contrast, injection of a larger amount resulted in incomplete (approximately 10%) renal clearance, probably due to uptake and metabolism of the oligosaccharide. In patients with glycogen storage diseases, certain malignancies, and pancreatitis, 24 h urinary Glc4 excretion exceeded the normal range. The diagnostic implications of these observations deserve evaluation. The results presented suggest a need for standardization of nutritional status and physical activity when monitoring urinary Glc4 excretion for diagnostic purposes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Urinary excretion, Tetrasaccharide, Glycogen metabolism
in
Clinica Chimica Acta
volume
176
issue
1
pages
39 - 48
publisher
Elsevier
external identifiers
  • pmid:3168292
  • scopus:0023677099
ISSN
0009-8981
DOI
10.1016/0009-8981(88)90172-6
language
English
LU publication?
yes
id
b8d56af3-89ee-4357-8f62-8e3edf22c890 (old id 1104159)
date added to LUP
2008-08-07 13:57:54
date last changed
2017-07-30 03:40:42
@article{b8d56af3-89ee-4357-8f62-8e3edf22c890,
  abstract     = {The urinary excretion of a glucose-containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with increased excretion of Glc4 after meals. A carbohydrate-rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a Rhesus monkey resulted in increased excretion of Glc4. When Glc4 itself was injected intravenously in small amounts renal clearance was rapid and complete. In contrast, injection of a larger amount resulted in incomplete (approximately 10%) renal clearance, probably due to uptake and metabolism of the oligosaccharide. In patients with glycogen storage diseases, certain malignancies, and pancreatitis, 24 h urinary Glc4 excretion exceeded the normal range. The diagnostic implications of these observations deserve evaluation. The results presented suggest a need for standardization of nutritional status and physical activity when monitoring urinary Glc4 excretion for diagnostic purposes.},
  author       = {Kumlien, Johan and Chester, Alan and Lindberg, Bo S and Pizzo, Phillip and Zopf, David and Lundblad, Arne},
  issn         = {0009-8981},
  keyword      = {Urinary excretion,Tetrasaccharide,Glycogen metabolism},
  language     = {eng},
  number       = {1},
  pages        = {39--48},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Urinary excretion of a glucose-containing tetrasaccharide. A parameter for increased degradation of glycogen},
  url          = {http://dx.doi.org/10.1016/0009-8981(88)90172-6},
  volume       = {176},
  year         = {1988},
}