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Oligosaccharides from faeces of a blood-group B, breast-fed infant

Sabharwal, Hemant; Nilsson, Bo; Chester, Alan LU ; Lindh, Frank; Grönberg, Gunnar; Sjöblad, Sture LU and Lundblad, Arne (1988) In Carbohydrate Research 178(1). p.145-154
Abstract
Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the... (More)
Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Carbohydrate Research
volume
178
issue
1
pages
145 - 154
publisher
Elsevier
external identifiers
  • pmid:3191506
  • scopus:0024288344
ISSN
1873-426X
DOI
10.1016/0008-6215(88)80107-1
language
English
LU publication?
yes
id
bb2a9271-4555-435a-ad33-577bac39212f (old id 1104166)
date added to LUP
2008-08-07 13:55:43
date last changed
2017-07-23 03:34:39
@article{bb2a9271-4555-435a-ad33-577bac39212f,
  abstract     = {Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active.},
  author       = {Sabharwal, Hemant and Nilsson, Bo and Chester, Alan and Lindh, Frank and Grönberg, Gunnar and Sjöblad, Sture and Lundblad, Arne},
  issn         = {1873-426X},
  language     = {eng},
  number       = {1},
  pages        = {145--154},
  publisher    = {Elsevier},
  series       = {Carbohydrate Research},
  title        = {Oligosaccharides from faeces of a blood-group B, breast-fed infant},
  url          = {http://dx.doi.org/10.1016/0008-6215(88)80107-1},
  volume       = {178},
  year         = {1988},
}