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Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis

Bergqvist, D; Mätzsch, Thomas LU ; Burmark, U S; Frisell, J; Guilbaud, O; Hallbook, T; Horn, A; Lindhagen, A; Ljungner, H and Ljungstrom, K G (1988) In British Journal of Surgery 75(9). p.888-891
Abstract
A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The frequency of deep vein thrombosis was significantly reduced among patients with correct prophylaxis with the heparin fragment (9.2-5.0 per cent, P = 0.02) [corrected]. The frequency of bleeding was... (More)
A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The frequency of deep vein thrombosis was significantly reduced among patients with correct prophylaxis with the heparin fragment (9.2-5.0 per cent, P = 0.02) [corrected]. The frequency of bleeding was 6.7 per cent among the heparin fragment patients and 2.7 per cent among the patients given conventional heparin (P = 0.01), but all bleeds were of minor degree and there was no difference in the reoperation rate for bleeding, or in the transfusion requirements. Local pain at the injection site was reported significantly less often among patients given the heparin fragment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Low molecular weight heparin, low dose heparin, postoperative thrombo-embolism, prophylaxis
in
British Journal of Surgery
volume
75
issue
9
pages
888 - 891
publisher
John Wiley & Sons
external identifiers
  • pmid:2846113
  • scopus:0023734137
ISSN
1365-2168
DOI
10.1002/bjs.1800750920
language
English
LU publication?
yes
id
2635db3e-89f9-40b4-a9a4-1219873cd05d (old id 1104306)
date added to LUP
2008-08-07 14:59:27
date last changed
2017-08-20 03:37:28
@article{2635db3e-89f9-40b4-a9a4-1219873cd05d,
  abstract     = {A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The frequency of deep vein thrombosis was significantly reduced among patients with correct prophylaxis with the heparin fragment (9.2-5.0 per cent, P = 0.02) [corrected]. The frequency of bleeding was 6.7 per cent among the heparin fragment patients and 2.7 per cent among the patients given conventional heparin (P = 0.01), but all bleeds were of minor degree and there was no difference in the reoperation rate for bleeding, or in the transfusion requirements. Local pain at the injection site was reported significantly less often among patients given the heparin fragment.},
  author       = {Bergqvist, D and Mätzsch, Thomas and Burmark, U S and Frisell, J and Guilbaud, O and Hallbook, T and Horn, A and Lindhagen, A and Ljungner, H and Ljungstrom, K G},
  issn         = {1365-2168},
  keyword      = {Low molecular weight heparin,low dose heparin,postoperative thrombo-embolism,prophylaxis},
  language     = {eng},
  number       = {9},
  pages        = {888--891},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis},
  url          = {http://dx.doi.org/10.1002/bjs.1800750920},
  volume       = {75},
  year         = {1988},
}