Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis
(1988) In British Journal of Surgery 75(9). p.888-891- Abstract
- A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The frequency of deep vein thrombosis was significantly reduced among patients with correct prophylaxis with the heparin fragment (9.2-5.0 per cent, P = 0.02) [corrected]. The frequency of bleeding was... (More)
- A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The frequency of deep vein thrombosis was significantly reduced among patients with correct prophylaxis with the heparin fragment (9.2-5.0 per cent, P = 0.02) [corrected]. The frequency of bleeding was 6.7 per cent among the heparin fragment patients and 2.7 per cent among the patients given conventional heparin (P = 0.01), but all bleeds were of minor degree and there was no difference in the reoperation rate for bleeding, or in the transfusion requirements. Local pain at the injection site was reported significantly less often among patients given the heparin fragment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104306
- author
- Bergqvist, D ; Mätzsch, Thomas LU ; Burmark, U S ; Frisell, J ; Guilbaud, O ; Hallbook, T ; Horn, A ; Lindhagen, A ; Ljungner, H and Ljungstrom, K G
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Low molecular weight heparin, low dose heparin, postoperative thrombo-embolism, prophylaxis
- in
- British Journal of Surgery
- volume
- 75
- issue
- 9
- pages
- 888 - 891
- publisher
- Oxford University Press
- external identifiers
-
- pmid:2846113
- scopus:0023734137
- ISSN
- 1365-2168
- DOI
- 10.1002/bjs.1800750920
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 2635db3e-89f9-40b4-a9a4-1219873cd05d (old id 1104306)
- date added to LUP
- 2016-04-01 12:02:48
- date last changed
- 2021-10-03 05:10:00
@article{2635db3e-89f9-40b4-a9a4-1219873cd05d,
abstract = {{A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having received correct prophylaxis. Of these 1002 patients, 64 per cent were operated on for malignant disease. A total of 20 patients died, 10 in each group. The frequency of deep vein thrombosis was significantly reduced among patients with correct prophylaxis with the heparin fragment (9.2-5.0 per cent, P = 0.02) [corrected]. The frequency of bleeding was 6.7 per cent among the heparin fragment patients and 2.7 per cent among the patients given conventional heparin (P = 0.01), but all bleeds were of minor degree and there was no difference in the reoperation rate for bleeding, or in the transfusion requirements. Local pain at the injection site was reported significantly less often among patients given the heparin fragment.}},
author = {{Bergqvist, D and Mätzsch, Thomas and Burmark, U S and Frisell, J and Guilbaud, O and Hallbook, T and Horn, A and Lindhagen, A and Ljungner, H and Ljungstrom, K G}},
issn = {{1365-2168}},
keywords = {{Low molecular weight heparin; low dose heparin; postoperative thrombo-embolism; prophylaxis}},
language = {{eng}},
number = {{9}},
pages = {{888--891}},
publisher = {{Oxford University Press}},
series = {{British Journal of Surgery}},
title = {{Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis}},
url = {{http://dx.doi.org/10.1002/bjs.1800750920}},
doi = {{10.1002/bjs.1800750920}},
volume = {{75}},
year = {{1988}},
}