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No increase of plasma malondialdehyde after primary coronary angioplasty for acute myocardial infarction.

Aström Olsson, Karin; Harnek, Jan LU ; Öhlin, Ann-Kristin LU ; Pavlidis, Natascia; Thorvinger, Björn LU and Öhlin, Hans LU (2002) In Scandinavian Cardiovascular Journal1997-01-01+01:00 36(4). p.237-240
Abstract
OBJECTIVE: Free radicals formed after coronary artery occlusion and reperfusion are assumed to produce myocardial stunning and possibly other forms of reperfusion injury as well. Malondialdehyde (MDA) is an end product in the lipid peroxidation chain reaction and is frequently used as a marker for free oxygen radical production. Increased levels of plasma MDA have been found following successful thrombolytic therapy. The aim of this study was to investigate whether plasma MDA levels also increase after successful primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction (AMI). DESIGN: In 23 patients with AMI, treated with primary PTCA, plasma MDA was analysed using a high-performance liquid chromatography... (More)
OBJECTIVE: Free radicals formed after coronary artery occlusion and reperfusion are assumed to produce myocardial stunning and possibly other forms of reperfusion injury as well. Malondialdehyde (MDA) is an end product in the lipid peroxidation chain reaction and is frequently used as a marker for free oxygen radical production. Increased levels of plasma MDA have been found following successful thrombolytic therapy. The aim of this study was to investigate whether plasma MDA levels also increase after successful primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction (AMI). DESIGN: In 23 patients with AMI, treated with primary PTCA, plasma MDA was analysed using a high-performance liquid chromatography method (HPLC). The results obtained with this method were compared with those obtained with a fluorimetric assay of thiobarbituric acid reactive substances (TBARS). This assay measures MDA but with a lower specificity. RESULTS: We found a significant decrease of plasma MDA from baseline 0.99 to 0.87 micro mol/l at 30 min and to 0.90 micro mol/l at 90 min following the primary PTCA (p = 0.048 and 0.014, respectively). No significant changes in TBARS method levels were observed. CONCLUSION: Instead of the expected increase in MDA following reperfusion we found a significant decrease. The results from measurements of MDA and TBARS were significantly incompatible. The results raise serious doubts as to the usefulness of increased plasma levels of MDA as a marker of oxidative stress caused by coronary reperfusion in patients treated with angioplasty. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Scandinavian Cardiovascular Journal1997-01-01+01:00
volume
36
issue
4
pages
237 - 240
publisher
Taylor & Francis
external identifiers
  • pmid:12201972
  • wos:000177742600009
  • scopus:0036352988
ISSN
1651-2006
DOI
10.1080/14017430260180409
language
English
LU publication?
yes
id
dbea2743-ec0d-4dc9-b547-e11020b09c44 (old id 110436)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12201972&dopt=Abstract
date added to LUP
2007-07-02 10:30:35
date last changed
2017-01-01 07:15:41
@article{dbea2743-ec0d-4dc9-b547-e11020b09c44,
  abstract     = {OBJECTIVE: Free radicals formed after coronary artery occlusion and reperfusion are assumed to produce myocardial stunning and possibly other forms of reperfusion injury as well. Malondialdehyde (MDA) is an end product in the lipid peroxidation chain reaction and is frequently used as a marker for free oxygen radical production. Increased levels of plasma MDA have been found following successful thrombolytic therapy. The aim of this study was to investigate whether plasma MDA levels also increase after successful primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction (AMI). DESIGN: In 23 patients with AMI, treated with primary PTCA, plasma MDA was analysed using a high-performance liquid chromatography method (HPLC). The results obtained with this method were compared with those obtained with a fluorimetric assay of thiobarbituric acid reactive substances (TBARS). This assay measures MDA but with a lower specificity. RESULTS: We found a significant decrease of plasma MDA from baseline 0.99 to 0.87 micro mol/l at 30 min and to 0.90 micro mol/l at 90 min following the primary PTCA (p = 0.048 and 0.014, respectively). No significant changes in TBARS method levels were observed. CONCLUSION: Instead of the expected increase in MDA following reperfusion we found a significant decrease. The results from measurements of MDA and TBARS were significantly incompatible. The results raise serious doubts as to the usefulness of increased plasma levels of MDA as a marker of oxidative stress caused by coronary reperfusion in patients treated with angioplasty.},
  author       = {Aström Olsson, Karin and Harnek, Jan and Öhlin, Ann-Kristin and Pavlidis, Natascia and Thorvinger, Björn and Öhlin, Hans},
  issn         = {1651-2006},
  language     = {eng},
  number       = {4},
  pages        = {237--240},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal1997-01-01+01:00},
  title        = {No increase of plasma malondialdehyde after primary coronary angioplasty for acute myocardial infarction.},
  url          = {http://dx.doi.org/10.1080/14017430260180409},
  volume       = {36},
  year         = {2002},
}