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A heterogeneous population of alpha 1-adrenoceptors mediates contraction of the isolated follicle wall from the bovine ovary

Kannisto, P; Owman, Christer LU ; Schmidt, G and Sjöberg, N O (1988) In Acta Physiologica Scandinavica 133(4). p.563-571
Abstract
Strips from Graafian follicles of bovine ovaries were tested for their contractile response in vitro in order to characterize the type of post-junctional alpha-adrenoceptor involved. Electrically induced contractions were inhibited concentration-dependently by the alpha 1-antagonist, prazosin. Besides noradrenaline the alpha 1-selective agonists, methoxamine and phenylephrine, caused the strips to contract, whereas the alpha 2-selective agonists clonidine, oxymetazoline and B-HT920 were without effect. However, the alpha 1-selective antagonist prazosin gave a line with a slope less than unity in the Schild plots with noradrenaline and methoxamine. From results obtained with or without the presence of two classes of neuronal uptake blockers... (More)
Strips from Graafian follicles of bovine ovaries were tested for their contractile response in vitro in order to characterize the type of post-junctional alpha-adrenoceptor involved. Electrically induced contractions were inhibited concentration-dependently by the alpha 1-antagonist, prazosin. Besides noradrenaline the alpha 1-selective agonists, methoxamine and phenylephrine, caused the strips to contract, whereas the alpha 2-selective agonists clonidine, oxymetazoline and B-HT920 were without effect. However, the alpha 1-selective antagonist prazosin gave a line with a slope less than unity in the Schild plots with noradrenaline and methoxamine. From results obtained with or without the presence of two classes of neuronal uptake blockers (desipramine and cocaine) it is concluded that the post-junctional alpha 1-receptor population is inhomogeneous. The regular appearance of the Schild plot obtained with phenylephrine may be due to involvement also of a component of noradrenaline release by this agonist. The pA2 value in the test with phenylephrine was 9.27, with a corresponding kB of 3.81 +/- 1.15 X 10(-10) M. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
133
issue
4
pages
563 - 571
publisher
Wiley-Blackwell
external identifiers
  • pmid:2906513
  • scopus:0023821758
ISSN
0001-6772
language
English
LU publication?
yes
id
eb3f2a82-fb57-4852-8c77-62eca9237ce7 (old id 1104451)
date added to LUP
2008-08-08 11:17:27
date last changed
2017-01-01 06:52:35
@article{eb3f2a82-fb57-4852-8c77-62eca9237ce7,
  abstract     = {Strips from Graafian follicles of bovine ovaries were tested for their contractile response in vitro in order to characterize the type of post-junctional alpha-adrenoceptor involved. Electrically induced contractions were inhibited concentration-dependently by the alpha 1-antagonist, prazosin. Besides noradrenaline the alpha 1-selective agonists, methoxamine and phenylephrine, caused the strips to contract, whereas the alpha 2-selective agonists clonidine, oxymetazoline and B-HT920 were without effect. However, the alpha 1-selective antagonist prazosin gave a line with a slope less than unity in the Schild plots with noradrenaline and methoxamine. From results obtained with or without the presence of two classes of neuronal uptake blockers (desipramine and cocaine) it is concluded that the post-junctional alpha 1-receptor population is inhomogeneous. The regular appearance of the Schild plot obtained with phenylephrine may be due to involvement also of a component of noradrenaline release by this agonist. The pA2 value in the test with phenylephrine was 9.27, with a corresponding kB of 3.81 +/- 1.15 X 10(-10) M.},
  author       = {Kannisto, P and Owman, Christer and Schmidt, G and Sjöberg, N O},
  issn         = {0001-6772},
  language     = {eng},
  number       = {4},
  pages        = {563--571},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {A heterogeneous population of alpha 1-adrenoceptors mediates contraction of the isolated follicle wall from the bovine ovary},
  volume       = {133},
  year         = {1988},
}