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Prevention of posttraumatic pulmonary platelet trapping by portacaval transposition

Elmér, Olle; Thörne, Johan LU ; Blomquist, Sten LU and Jönsson, Bo-Anders LU (1988) In American Journal of Surgery 155(2). p.289-292
Abstract
Significant soft-tissue trauma induces platelet activation, aggregation, and sequestration in the lungs. This pulmonary trapping is due either to the size of the platelet aggregates or to changes in the pulmonary microvasculature. To evaluate which one of these mechanisms is responsible for the trapping, we performed portacaval transposition in one group of pigs, making the liver the first receiving capillary bed for blood from the trauma sites in the lower extremities. One week after the operation, the platelets were labeled with indium oxine and reinfused, and the operated animals and a group of six control animals were subjected to standardized soft-tissue trauma to the lower extremities. Sequestration of platelets in the lungs and in... (More)
Significant soft-tissue trauma induces platelet activation, aggregation, and sequestration in the lungs. This pulmonary trapping is due either to the size of the platelet aggregates or to changes in the pulmonary microvasculature. To evaluate which one of these mechanisms is responsible for the trapping, we performed portacaval transposition in one group of pigs, making the liver the first receiving capillary bed for blood from the trauma sites in the lower extremities. One week after the operation, the platelets were labeled with indium oxine and reinfused, and the operated animals and a group of six control animals were subjected to standardized soft-tissue trauma to the lower extremities. Sequestration of platelets in the lungs and in the liver was registered dynamically before and for 90 minutes after the trauma. Soft-tissue trauma induced platelet sequestration in the liver in the operated group (p less than 0.01) and in the lungs in the control group (p less than 0.01). Trapping was paralleled by a decrease in the number of circulating platelets. This study has indicated that posttraumatic pulmonary platelet trapping is caused by platelet activation at the trauma sites and not by changes in the pulmonary microvasculature. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Surgery
volume
155
issue
2
pages
289 - 292
publisher
Elsevier
external identifiers
  • scopus:0023945426
ISSN
1879-1883
DOI
10.1016/S0002-9610(88)80716-5
language
English
LU publication?
yes
id
e17d7b49-eb46-4ba0-8500-c6b941d55090 (old id 1104459)
date added to LUP
2008-08-08 11:26:08
date last changed
2017-01-01 04:21:12
@article{e17d7b49-eb46-4ba0-8500-c6b941d55090,
  abstract     = {Significant soft-tissue trauma induces platelet activation, aggregation, and sequestration in the lungs. This pulmonary trapping is due either to the size of the platelet aggregates or to changes in the pulmonary microvasculature. To evaluate which one of these mechanisms is responsible for the trapping, we performed portacaval transposition in one group of pigs, making the liver the first receiving capillary bed for blood from the trauma sites in the lower extremities. One week after the operation, the platelets were labeled with indium oxine and reinfused, and the operated animals and a group of six control animals were subjected to standardized soft-tissue trauma to the lower extremities. Sequestration of platelets in the lungs and in the liver was registered dynamically before and for 90 minutes after the trauma. Soft-tissue trauma induced platelet sequestration in the liver in the operated group (p less than 0.01) and in the lungs in the control group (p less than 0.01). Trapping was paralleled by a decrease in the number of circulating platelets. This study has indicated that posttraumatic pulmonary platelet trapping is caused by platelet activation at the trauma sites and not by changes in the pulmonary microvasculature.},
  author       = {Elmér, Olle and Thörne, Johan and Blomquist, Sten and Jönsson, Bo-Anders},
  issn         = {1879-1883},
  language     = {eng},
  number       = {2},
  pages        = {289--292},
  publisher    = {Elsevier},
  series       = {American Journal of Surgery},
  title        = {Prevention of posttraumatic pulmonary platelet trapping by portacaval transposition},
  url          = {http://dx.doi.org/10.1016/S0002-9610(88)80716-5},
  volume       = {155},
  year         = {1988},
}