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Laser Doppler flowmetry during hyperaemic reactions in the skin

Svensson, Henry LU and Jönsson, Bo-Anders LU (1988) In International journal of microcirculation, clinical and experimental 7(1). p.87-96
Abstract
Laser Doppler flowmetry (LDF) was used to study skin blood flow in the finger tip and on the dorsum of the hand in healthy volunteers. Vasodilatation in the finger tip was induced by immersing the arm in water at 42 degrees C, and vasodilatation in the dorsum of the hand by intracutaneous injection of dihydralazine. Simultaneous measurements were performed using venous occlusion plethysmography (finger tip) and 133Xe clearance (dorsum of hand). Three output signals from the laser Doppler flowmeter were recorded. The LDFPf-1 value is linearly related to the blood flow, provided the concentration of blood cells in the scattering volume is low. The LDFPf-2 value is generated by a signal processor designed to give linearity even at higher... (More)
Laser Doppler flowmetry (LDF) was used to study skin blood flow in the finger tip and on the dorsum of the hand in healthy volunteers. Vasodilatation in the finger tip was induced by immersing the arm in water at 42 degrees C, and vasodilatation in the dorsum of the hand by intracutaneous injection of dihydralazine. Simultaneous measurements were performed using venous occlusion plethysmography (finger tip) and 133Xe clearance (dorsum of hand). Three output signals from the laser Doppler flowmeter were recorded. The LDFPf-1 value is linearly related to the blood flow, provided the concentration of blood cells in the scattering volume is low. The LDFPf-2 value is generated by a signal processor designed to give linearity even at higher concentrations of moving blood cells (CMBC), the latter quantity being reflected by the CMBC value. During vasodilatation by immersion, all laser Doppler values from the finger tip increased but less than the total finger blood flow as measured using venous occlusion plethysmography. Intracutaneous injection of dihydralazine in the dorsum of the hand caused markedly increased CMBC values and the increase in LDFPf-2 was significantly greater than that of LDFPf-1. The increase in 133Xe clearance was less pronounced. The results indicate that capillary blood flow as well as blood flow in vessels below the capillary level contribute to the Doppler signal. However, flow through the arteriovenous shunts in the finger tip seems to be only partially registered by the laser Doppler technique. The higher the CMBC value, the more obvious is the difference between LDFPf-1 and LDFPf-2 values. When using laser Doppler flowmetry, the addition of CMBC value registration may be helpful in clarifying changes in microvascular blood flow. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International journal of microcirculation, clinical and experimental
volume
7
issue
1
pages
87 - 96
publisher
Karger
external identifiers
  • scopus:0023800148
ISSN
0167-6865
language
English
LU publication?
yes
id
1843c4c6-23ca-40ea-bab2-0ff0dc87757e (old id 1104469)
date added to LUP
2008-08-08 11:38:24
date last changed
2017-08-20 04:27:57
@article{1843c4c6-23ca-40ea-bab2-0ff0dc87757e,
  abstract     = {Laser Doppler flowmetry (LDF) was used to study skin blood flow in the finger tip and on the dorsum of the hand in healthy volunteers. Vasodilatation in the finger tip was induced by immersing the arm in water at 42 degrees C, and vasodilatation in the dorsum of the hand by intracutaneous injection of dihydralazine. Simultaneous measurements were performed using venous occlusion plethysmography (finger tip) and 133Xe clearance (dorsum of hand). Three output signals from the laser Doppler flowmeter were recorded. The LDFPf-1 value is linearly related to the blood flow, provided the concentration of blood cells in the scattering volume is low. The LDFPf-2 value is generated by a signal processor designed to give linearity even at higher concentrations of moving blood cells (CMBC), the latter quantity being reflected by the CMBC value. During vasodilatation by immersion, all laser Doppler values from the finger tip increased but less than the total finger blood flow as measured using venous occlusion plethysmography. Intracutaneous injection of dihydralazine in the dorsum of the hand caused markedly increased CMBC values and the increase in LDFPf-2 was significantly greater than that of LDFPf-1. The increase in 133Xe clearance was less pronounced. The results indicate that capillary blood flow as well as blood flow in vessels below the capillary level contribute to the Doppler signal. However, flow through the arteriovenous shunts in the finger tip seems to be only partially registered by the laser Doppler technique. The higher the CMBC value, the more obvious is the difference between LDFPf-1 and LDFPf-2 values. When using laser Doppler flowmetry, the addition of CMBC value registration may be helpful in clarifying changes in microvascular blood flow.},
  author       = {Svensson, Henry and Jönsson, Bo-Anders},
  issn         = {0167-6865},
  language     = {eng},
  number       = {1},
  pages        = {87--96},
  publisher    = {Karger},
  series       = {International journal of microcirculation, clinical and experimental},
  title        = {Laser Doppler flowmetry during hyperaemic reactions in the skin},
  volume       = {7},
  year         = {1988},
}