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Comparison of the mitogenic activities of streptococcal protein-G and staphylococcal protein-A on human mononuclear cells

Lindhqvist, Violetta; Niss, Ulf and Nilsson, Rune LU (1989) In Immunological Investigations 18(7). p.919-930
Abstract
In the present work we report data from experiments comparing the proliferative stimuli demonstrated by Streptococcal Protein-G and Staphylococcal Protein A on human peripheral blood mononuclear cells. Protein-G and Protein-A are presented to the cells in solution as well as linked to plastic or Sepharose beads, or incorporated within the cell wall of whole bacteria. The cellular response is measured by incorporation of 3H-thymidine in 72 hr cultures. The soluble and the immobilized forms of Protein-A, but not those of Protein-G, displayed high mitogenicity. Possible explanations for the absence of Protein-G induced mitogenicity are discussed.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunological Investigations
volume
18
issue
7
pages
919 - 930
publisher
Marcel Dekker
external identifiers
  • pmid:2793212
  • scopus:0024446992
ISSN
0882-0139
DOI
10.3109/08820138909050770
language
English
LU publication?
yes
id
ced7a15c-c565-4811-b1db-ab81515e3dd4 (old id 1104536)
date added to LUP
2008-08-06 09:51:49
date last changed
2017-01-01 07:10:48
@article{ced7a15c-c565-4811-b1db-ab81515e3dd4,
  abstract     = {In the present work we report data from experiments comparing the proliferative stimuli demonstrated by Streptococcal Protein-G and Staphylococcal Protein A on human peripheral blood mononuclear cells. Protein-G and Protein-A are presented to the cells in solution as well as linked to plastic or Sepharose beads, or incorporated within the cell wall of whole bacteria. The cellular response is measured by incorporation of 3H-thymidine in 72 hr cultures. The soluble and the immobilized forms of Protein-A, but not those of Protein-G, displayed high mitogenicity. Possible explanations for the absence of Protein-G induced mitogenicity are discussed.},
  author       = {Lindhqvist, Violetta and Niss, Ulf and Nilsson, Rune},
  issn         = {0882-0139},
  language     = {eng},
  number       = {7},
  pages        = {919--930},
  publisher    = {Marcel Dekker},
  series       = {Immunological Investigations},
  title        = {Comparison of the mitogenic activities of streptococcal protein-G and staphylococcal protein-A on human mononuclear cells},
  url          = {http://dx.doi.org/10.3109/08820138909050770},
  volume       = {18},
  year         = {1989},
}