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Nicotine does not affect plasma lipoprotein concentrations in healthy men

Quensel, M; Agardh, Carl-David LU and Nilsson-Ehle, Peter LU (1989) In Scandinavian Journal of Clinical & Laboratory Investigation 49(2). p.149-153
Abstract
The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not... (More)
The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not mediated via nicotine, and indicate that nicotine chewing gum, when used therapeutically in anti-smoking programmes, does not carry the same metabolic side effects as smoking. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
plasma lipoproteins, plasma lipids, nicotine intake, lipolytic enzymes, cotinine concentrations
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
49
issue
2
pages
149 - 153
publisher
Informa Healthcare
external identifiers
  • pmid:2520366
  • scopus:0024588516
ISSN
1502-7686
DOI
10.3109/00365518909105414
language
English
LU publication?
yes
id
dcfac300-3a73-4524-8224-a81c3e441231 (old id 1104575)
date added to LUP
2008-08-06 11:03:53
date last changed
2017-08-06 04:42:30
@article{dcfac300-3a73-4524-8224-a81c3e441231,
  abstract     = {The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not mediated via nicotine, and indicate that nicotine chewing gum, when used therapeutically in anti-smoking programmes, does not carry the same metabolic side effects as smoking.},
  author       = {Quensel, M and Agardh, Carl-David and Nilsson-Ehle, Peter},
  issn         = {1502-7686},
  keyword      = {plasma lipoproteins,plasma lipids,nicotine intake,lipolytic enzymes,cotinine concentrations},
  language     = {eng},
  number       = {2},
  pages        = {149--153},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Nicotine does not affect plasma lipoprotein concentrations in healthy men},
  url          = {http://dx.doi.org/10.3109/00365518909105414},
  volume       = {49},
  year         = {1989},
}