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Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery

Chang, J Y and Owman, Christer LU (1989) In Journal of Cerebral Blood Flow and Metabolism 9(5). p.713-716
Abstract
Based on the previous finding that 5-hydroxytryptamine (5-HT) co-exists with norepinephrine (NE) in cerebrovascular sympathetic nerve fibers and can be released during electrical nerve stimulation, the postjunctional interaction between the two amines was studied in isolated basilar artery of guinea pig. A low concentration of 5-HT, which in itself has little or no constrictive effect, potentiated the weak contraction of NE by almost 300%. The amplification was antagonized by methiothepin, but not by ketanserin, and it could be mimicked by methysergide. The marked potentiation is thus probably associated with the 5-HT1-like receptors, which earlier have been found to mediate the direct vasoconstrictive action of 5-HT in this vessel... (More)
Based on the previous finding that 5-hydroxytryptamine (5-HT) co-exists with norepinephrine (NE) in cerebrovascular sympathetic nerve fibers and can be released during electrical nerve stimulation, the postjunctional interaction between the two amines was studied in isolated basilar artery of guinea pig. A low concentration of 5-HT, which in itself has little or no constrictive effect, potentiated the weak contraction of NE by almost 300%. The amplification was antagonized by methiothepin, but not by ketanserin, and it could be mimicked by methysergide. The marked potentiation is thus probably associated with the 5-HT1-like receptors, which earlier have been found to mediate the direct vasoconstrictive action of 5-HT in this vessel preparation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
9
issue
5
pages
713 - 716
publisher
Nature Publishing Group
external identifiers
  • pmid:2777937
  • scopus:0024467701
ISSN
1559-7016
language
English
LU publication?
yes
id
f5cd5108-d65d-4e15-8bae-0b0ebd620ed1 (old id 1104658)
date added to LUP
2008-08-06 12:36:53
date last changed
2017-01-01 06:42:17
@article{f5cd5108-d65d-4e15-8bae-0b0ebd620ed1,
  abstract     = {Based on the previous finding that 5-hydroxytryptamine (5-HT) co-exists with norepinephrine (NE) in cerebrovascular sympathetic nerve fibers and can be released during electrical nerve stimulation, the postjunctional interaction between the two amines was studied in isolated basilar artery of guinea pig. A low concentration of 5-HT, which in itself has little or no constrictive effect, potentiated the weak contraction of NE by almost 300%. The amplification was antagonized by methiothepin, but not by ketanserin, and it could be mimicked by methysergide. The marked potentiation is thus probably associated with the 5-HT1-like receptors, which earlier have been found to mediate the direct vasoconstrictive action of 5-HT in this vessel preparation.},
  author       = {Chang, J Y and Owman, Christer},
  issn         = {1559-7016},
  language     = {eng},
  number       = {5},
  pages        = {713--716},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery},
  volume       = {9},
  year         = {1989},
}