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Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats

Owman, Christer LU ; Fuxe, K ; Janson, A M and Kahrstrom, J (1989) In Neuroscience Letters 102(2-3). p.279-283
Abstract
Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h following the lesion. The total treatment corresponded to a mean plasma level of 50 ng/ml nicotine, measured at the end of the experiment. Control animals received corresponding volumes of 0.9% saline. Quantitative autoradiographic analysis of the glucose utilization in the caudate nucleus using Sokoloff's [14C]2-deoxyglucose method demonstrated a... (More)
Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h following the lesion. The total treatment corresponded to a mean plasma level of 50 ng/ml nicotine, measured at the end of the experiment. Control animals received corresponding volumes of 0.9% saline. Quantitative autoradiographic analysis of the glucose utilization in the caudate nucleus using Sokoloff's [14C]2-deoxyglucose method demonstrated a 16% side-to-side difference in the lesioned control animals, whereas the asymmetry was counteracted by the nicotine treatment. Although there was an overall tendency to a lower rate of glucose utilization (by 6%) in the nicotine-treated animals compared to the controls receiving saline only, the difference was not statistically significant. The eliminated asymmetry probably reflects an increased survival of the dopamine neurons and/or of striatal nerve cells on the lesioned side due to protective effects of nicotine resulting from desensitization of nicotinic-type cholinergic receptors following continuous administration of the drug. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dopamine, Rat, Caudate nucleus, Glucose utilization, Mesostriatal system, Partial hemitransection, Nicotine
in
Neuroscience Letters
volume
102
issue
2-3
pages
279 - 283
publisher
Elsevier
external identifiers
  • pmid:2812507
  • scopus:0024320344
ISSN
0304-3940
DOI
10.1016/0304-3940(89)90092-X
language
English
LU publication?
yes
id
9ba817dc-b5f6-4760-ae0d-def51cdc0ddf (old id 1104660)
date added to LUP
2016-04-01 12:07:59
date last changed
2021-01-03 06:45:51
@article{9ba817dc-b5f6-4760-ae0d-def51cdc0ddf,
  abstract     = {Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h following the lesion. The total treatment corresponded to a mean plasma level of 50 ng/ml nicotine, measured at the end of the experiment. Control animals received corresponding volumes of 0.9% saline. Quantitative autoradiographic analysis of the glucose utilization in the caudate nucleus using Sokoloff's [14C]2-deoxyglucose method demonstrated a 16% side-to-side difference in the lesioned control animals, whereas the asymmetry was counteracted by the nicotine treatment. Although there was an overall tendency to a lower rate of glucose utilization (by 6%) in the nicotine-treated animals compared to the controls receiving saline only, the difference was not statistically significant. The eliminated asymmetry probably reflects an increased survival of the dopamine neurons and/or of striatal nerve cells on the lesioned side due to protective effects of nicotine resulting from desensitization of nicotinic-type cholinergic receptors following continuous administration of the drug.},
  author       = {Owman, Christer and Fuxe, K and Janson, A M and Kahrstrom, J},
  issn         = {0304-3940},
  language     = {eng},
  number       = {2-3},
  pages        = {279--283},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats},
  url          = {http://dx.doi.org/10.1016/0304-3940(89)90092-X},
  doi          = {10.1016/0304-3940(89)90092-X},
  volume       = {102},
  year         = {1989},
}