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Changes in transport functions of isolated rabbit choroid plexus under the influence of oestrogen and progesterone

Lindvall-Axelsson, M and Owman, Christer LU (1989) In Acta Physiologica Scandinavica 136(1). p.107-111
Abstract
Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was... (More)
Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was not significantly affected by any of the hormones. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
136
issue
1
pages
107 - 111
publisher
Wiley-Blackwell
external identifiers
  • pmid:2549764
  • scopus:0024660670
ISSN
0001-6772
language
English
LU publication?
yes
id
01c141b3-7fdc-4b08-b7d2-78d2f4d12263 (old id 1104683)
date added to LUP
2008-08-06 13:31:45
date last changed
2017-01-01 07:03:19
@article{01c141b3-7fdc-4b08-b7d2-78d2f4d12263,
  abstract     = {Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was not significantly affected by any of the hormones.},
  author       = {Lindvall-Axelsson, M and Owman, Christer},
  issn         = {0001-6772},
  language     = {eng},
  number       = {1},
  pages        = {107--111},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {Changes in transport functions of isolated rabbit choroid plexus under the influence of oestrogen and progesterone},
  volume       = {136},
  year         = {1989},
}