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Changes in transport functions of isolated rabbit choroid plexus under the influence of oestrogen and progesterone

Lindvall-Axelsson, M and Owman, Christer LU (1989) In Acta Physiologica Scandinavica 136(1). p.107-111
Abstract
Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was... (More)
Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was not significantly affected by any of the hormones. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
136
issue
1
pages
107 - 111
publisher
Wiley-Blackwell
external identifiers
  • pmid:2549764
  • scopus:0024660670
ISSN
0001-6772
language
English
LU publication?
yes
id
01c141b3-7fdc-4b08-b7d2-78d2f4d12263 (old id 1104683)
date added to LUP
2016-04-01 16:22:03
date last changed
2021-01-03 07:07:51
@article{01c141b3-7fdc-4b08-b7d2-78d2f4d12263,
  abstract     = {{Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was not significantly affected by any of the hormones.}},
  author       = {{Lindvall-Axelsson, M and Owman, Christer}},
  issn         = {{0001-6772}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{107--111}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica Scandinavica}},
  title        = {{Changes in transport functions of isolated rabbit choroid plexus under the influence of oestrogen and progesterone}},
  volume       = {{136}},
  year         = {{1989}},
}