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Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat

Janson, A M; Fuxe, K; Agnati, L F; Jansson, A; Bjelke, B; Sundstrom, E; Andersson, K; Harfstrand, A; Goldstein, M and Owman, Christer LU (1989) In Progress in Brain Research 79. p.257-265
Abstract
The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can be extended to include also other injured neurons such as the cholinergic neurons, known to be severely affected in Alzheimer's disease.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Brain Research
volume
79
pages
257 - 265
publisher
Elsevier
external identifiers
  • pmid:2587746
  • scopus:0024852273
ISSN
1875-7855
language
English
LU publication?
yes
id
fb6157a8-0065-498c-91c8-bac51e160dd6 (old id 1104685)
date added to LUP
2008-08-06 13:33:31
date last changed
2017-07-30 04:29:36
@article{fb6157a8-0065-498c-91c8-bac51e160dd6,
  abstract     = {The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can be extended to include also other injured neurons such as the cholinergic neurons, known to be severely affected in Alzheimer's disease.},
  author       = {Janson, A M and Fuxe, K and Agnati, L F and Jansson, A and Bjelke, B and Sundstrom, E and Andersson, K and Harfstrand, A and Goldstein, M and Owman, Christer},
  issn         = {1875-7855},
  language     = {eng},
  pages        = {257--265},
  publisher    = {Elsevier},
  series       = {Progress in Brain Research},
  title        = {Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat},
  volume       = {79},
  year         = {1989},
}