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Ethanol potentiates serotonin stimulated inositol lipid metabolism in primary astroglial cell cultures

Simonsson, Per LU ; Hansson, Elisabeth and Alling, Christer LU (1989) In Biochemical Pharmacology 38(17). p.2801-2805
Abstract
Serotonin-stimulated activation of phospholipase C in primary astroglial cell cultures was studied as a mean of evaluating the effect of acute ethanol exposition on this signal transduction system. The addition of 50-150 mM ethanol prior to stimulation with 10(-5) M serotonin led to a potentiation of the serotonin-induced [3H]-inositol phosphate formation and an increased incorporation of [3H]-inositol into the three phosphoinositides studied. This potentiating effect of ethanol was observed only when ethanol was added together with serotonin. No stimulatory effect of ethanol per se was found. Furthermore, ethanol had no effect on arginine-vasopressin, bradykinin or phenylephrine stimulated inositol lipid metabolism.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical Pharmacology
volume
38
issue
17
pages
2801 - 2805
publisher
Elsevier
external identifiers
  • pmid:2775305
  • scopus:0024462873
ISSN
0006-2952
DOI
10.1016/0006-2952(89)90434-6
language
English
LU publication?
yes
id
5e84bfed-e596-465e-8f43-7d95ff64b5a8 (old id 1104756)
date added to LUP
2008-08-06 14:35:26
date last changed
2017-08-27 03:54:50
@article{5e84bfed-e596-465e-8f43-7d95ff64b5a8,
  abstract     = {Serotonin-stimulated activation of phospholipase C in primary astroglial cell cultures was studied as a mean of evaluating the effect of acute ethanol exposition on this signal transduction system. The addition of 50-150 mM ethanol prior to stimulation with 10(-5) M serotonin led to a potentiation of the serotonin-induced [3H]-inositol phosphate formation and an increased incorporation of [3H]-inositol into the three phosphoinositides studied. This potentiating effect of ethanol was observed only when ethanol was added together with serotonin. No stimulatory effect of ethanol per se was found. Furthermore, ethanol had no effect on arginine-vasopressin, bradykinin or phenylephrine stimulated inositol lipid metabolism.},
  author       = {Simonsson, Per and Hansson, Elisabeth and Alling, Christer},
  issn         = {0006-2952},
  language     = {eng},
  number       = {17},
  pages        = {2801--2805},
  publisher    = {Elsevier},
  series       = {Biochemical Pharmacology},
  title        = {Ethanol potentiates serotonin stimulated inositol lipid metabolism in primary astroglial cell cultures},
  url          = {http://dx.doi.org/10.1016/0006-2952(89)90434-6},
  volume       = {38},
  year         = {1989},
}