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Flow cytometric DNA ploidy and number of cell populations in the primary breast cancer and their correlation to the prognosis.

Ewers, Sven-Börje LU ; Baldetorp, Bo LU ; Killander, Dick LU and Långström-Einarsson, Eva LU (1989) In Acta Oncologica 28(6). p.913-918
Abstract
In a prospective study on 516 breast cancer patients flow cytometry DNA ploidy and number of cell populations (defined as number of DNA stem lines) detected in the primary tumor were evaluated for prognostic purposes. the median follow-up time was about 5 years. in the 241 node negative cases, those patients with three or more cell populations had the worst prognosis, with a distant recurrence-free survival rate of about 60% at five years compared to 90% in cases with only one cell population detected in the primary tumor. the number of tumor involved axillary lymph nodes was the outstanding prognostic indicator which was confirmed in 275 node positive patients; DNA ploidy and number of cell populations did not give any significant... (More)
In a prospective study on 516 breast cancer patients flow cytometry DNA ploidy and number of cell populations (defined as number of DNA stem lines) detected in the primary tumor were evaluated for prognostic purposes. the median follow-up time was about 5 years. in the 241 node negative cases, those patients with three or more cell populations had the worst prognosis, with a distant recurrence-free survival rate of about 60% at five years compared to 90% in cases with only one cell population detected in the primary tumor. the number of tumor involved axillary lymph nodes was the outstanding prognostic indicator which was confirmed in 275 node positive patients; DNA ploidy and number of cell populations did not give any significant prognostic information in this group of patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cell populations, DNA ploidy, flow cytometry, stage, prognosis, Breast cancer
in
Acta Oncologica
volume
28
issue
6
pages
913 - 918
publisher
Taylor & Francis
external identifiers
  • scopus:0024806493
ISSN
1651-226X
DOI
10.3109/02841868909092331
language
English
LU publication?
yes
id
4412af4d-a438-44fa-a01b-551d30bcb678 (old id 1104773)
date added to LUP
2008-08-06 14:49:02
date last changed
2017-08-06 04:41:19
@article{4412af4d-a438-44fa-a01b-551d30bcb678,
  abstract     = {In a prospective study on 516 breast cancer patients flow cytometry DNA ploidy and number of cell populations (defined as number of DNA stem lines) detected in the primary tumor were evaluated for prognostic purposes. the median follow-up time was about 5 years. in the 241 node negative cases, those patients with three or more cell populations had the worst prognosis, with a distant recurrence-free survival rate of about 60% at five years compared to 90% in cases with only one cell population detected in the primary tumor. the number of tumor involved axillary lymph nodes was the outstanding prognostic indicator which was confirmed in 275 node positive patients; DNA ploidy and number of cell populations did not give any significant prognostic information in this group of patients.},
  author       = {Ewers, Sven-Börje and Baldetorp, Bo and Killander, Dick and Långström-Einarsson, Eva},
  issn         = {1651-226X},
  keyword      = {cell populations,DNA ploidy,flow cytometry,stage,prognosis,Breast cancer},
  language     = {eng},
  number       = {6},
  pages        = {913--918},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Flow cytometric DNA ploidy and number of cell populations in the primary breast cancer and their correlation to the prognosis.},
  url          = {http://dx.doi.org/10.3109/02841868909092331},
  volume       = {28},
  year         = {1989},
}