Advanced

Predisposing factors in laboratory animal allergy: a study of atopy and environmental factors

Sjöstedt, Lars and Willers, Stefan LU (1989) In American Journal of Industrial Medicine 16(2). p.199-208
Abstract
A population of 101 laboratory technicians handling laboratory animals was studied with regard to predisposing factors for allergy. Twenty-seven had symptoms indicating laboratory animal allergy (LAA); of these, nine had asthma and were skin prick test positive for animal allergens. The LAA asthmatics had an increased frequency of a family history of allergy (relative risk, RR = 3.8); the predictive value was 0.27. There was also an increase of skin prick positivity against common nonanimal allergens (RR = 15); the predictive value was 0.60. All persons with marked positive skin prick tests (greater than or equal to +2) to environmental allergens had developed animal-test-positive LAA asthma. In 56% of the LAA asthma cases the serum IgE... (More)
A population of 101 laboratory technicians handling laboratory animals was studied with regard to predisposing factors for allergy. Twenty-seven had symptoms indicating laboratory animal allergy (LAA); of these, nine had asthma and were skin prick test positive for animal allergens. The LAA asthmatics had an increased frequency of a family history of allergy (relative risk, RR = 3.8); the predictive value was 0.27. There was also an increase of skin prick positivity against common nonanimal allergens (RR = 15); the predictive value was 0.60. All persons with marked positive skin prick tests (greater than or equal to +2) to environmental allergens had developed animal-test-positive LAA asthma. In 56% of the LAA asthma cases the serum IgE levels were elevated (greater than 100kU/L). In preemployment screening of susceptible individuals two important selection criteria emerged, viz., family history of allergy and positive skin prick reactions against environmental allergens. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asthma, domestic animals, allergy atopy, IgE, LAA, passive smoking, rhinoconjunctivitis, skin prick testing, laboratory work
in
American Journal of Industrial Medicine
volume
16
issue
2
pages
199 - 208
publisher
John Wiley & Sons
external identifiers
  • pmid:2773948
  • scopus:0024314604
ISSN
0271-3586
DOI
10.1002/ajim.4700160211
language
English
LU publication?
yes
id
0d690874-114f-4dfe-8ca6-27a5855f1a5e (old id 1104799)
date added to LUP
2008-08-06 15:36:33
date last changed
2017-08-20 03:41:06
@article{0d690874-114f-4dfe-8ca6-27a5855f1a5e,
  abstract     = {A population of 101 laboratory technicians handling laboratory animals was studied with regard to predisposing factors for allergy. Twenty-seven had symptoms indicating laboratory animal allergy (LAA); of these, nine had asthma and were skin prick test positive for animal allergens. The LAA asthmatics had an increased frequency of a family history of allergy (relative risk, RR = 3.8); the predictive value was 0.27. There was also an increase of skin prick positivity against common nonanimal allergens (RR = 15); the predictive value was 0.60. All persons with marked positive skin prick tests (greater than or equal to +2) to environmental allergens had developed animal-test-positive LAA asthma. In 56% of the LAA asthma cases the serum IgE levels were elevated (greater than 100kU/L). In preemployment screening of susceptible individuals two important selection criteria emerged, viz., family history of allergy and positive skin prick reactions against environmental allergens.},
  author       = {Sjöstedt, Lars and Willers, Stefan},
  issn         = {0271-3586},
  keyword      = {asthma,domestic animals,allergy atopy,IgE,LAA,passive smoking,rhinoconjunctivitis,skin prick testing,laboratory work},
  language     = {eng},
  number       = {2},
  pages        = {199--208},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Industrial Medicine},
  title        = {Predisposing factors in laboratory animal allergy: a study of atopy and environmental factors},
  url          = {http://dx.doi.org/10.1002/ajim.4700160211},
  volume       = {16},
  year         = {1989},
}