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Ultrasound nucleolysis: an in vitro study.

Persson, Johan K LU ; Strömqvist, Björn LU ; Zanoli, Gustavo LU ; McCarthy, Ian LU and Lidgren, Lars LU (2002) In Ultrasound in Medicine and Biology 28(9). p.1189-1197
Abstract
Thermal intradiscal therapy for chronic low back pain, using a catheter inserted into the intervertebral disc, is becoming more popular in the treatment of low back pain. The aim of this study was to investigate the possibility of heating the nucleus pulposus of the intervertebral disc with high-intensity focused ultrasound (US) or HIFU. Two specific situations were considered, invasive transducers that would be in contact with the annulus fibrosus of the disc, and noninvasive transducers that could be used externally. Theoretical simulations were performed to find the optimal parameters of US transducers and then experimental studies were done using transducers made to these specifications. These experiments confirmed that it was possible... (More)
Thermal intradiscal therapy for chronic low back pain, using a catheter inserted into the intervertebral disc, is becoming more popular in the treatment of low back pain. The aim of this study was to investigate the possibility of heating the nucleus pulposus of the intervertebral disc with high-intensity focused ultrasound (US) or HIFU. Two specific situations were considered, invasive transducers that would be in contact with the annulus fibrosus of the disc, and noninvasive transducers that could be used externally. Theoretical simulations were performed to find the optimal parameters of US transducers and then experimental studies were done using transducers made to these specifications. These experiments confirmed that it was possible to heat the discs with HIFU. Two orthogonal transducers resulted in a superior temperature distribution than using just one transducer. It is, therefore, feasible to consider thermal treatment of the nucleus pulposus of the disc using noninvasive US. (E-mail: Johan.Persson@ort.lu.se) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Ultrasound in Medicine and Biology
volume
28
issue
9
pages
1189 - 1197
publisher
Elsevier
external identifiers
  • wos:000178732200013
  • pmid:12401390
  • scopus:0036750206
ISSN
0301-5629
DOI
10.1016/S0301-5629(02)00566-5
language
English
LU publication?
yes
id
07e9e95b-d843-4bb4-a61c-90c578fc4a24 (old id 110491)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12401390&dopt=Abstract
date added to LUP
2007-07-03 17:03:42
date last changed
2017-08-06 03:35:37
@article{07e9e95b-d843-4bb4-a61c-90c578fc4a24,
  abstract     = {Thermal intradiscal therapy for chronic low back pain, using a catheter inserted into the intervertebral disc, is becoming more popular in the treatment of low back pain. The aim of this study was to investigate the possibility of heating the nucleus pulposus of the intervertebral disc with high-intensity focused ultrasound (US) or HIFU. Two specific situations were considered, invasive transducers that would be in contact with the annulus fibrosus of the disc, and noninvasive transducers that could be used externally. Theoretical simulations were performed to find the optimal parameters of US transducers and then experimental studies were done using transducers made to these specifications. These experiments confirmed that it was possible to heat the discs with HIFU. Two orthogonal transducers resulted in a superior temperature distribution than using just one transducer. It is, therefore, feasible to consider thermal treatment of the nucleus pulposus of the disc using noninvasive US. (E-mail: Johan.Persson@ort.lu.se)},
  author       = {Persson, Johan K and Strömqvist, Björn and Zanoli, Gustavo and McCarthy, Ian and Lidgren, Lars},
  issn         = {0301-5629},
  language     = {eng},
  number       = {9},
  pages        = {1189--1197},
  publisher    = {Elsevier},
  series       = {Ultrasound in Medicine and Biology},
  title        = {Ultrasound nucleolysis: an in vitro study.},
  url          = {http://dx.doi.org/10.1016/S0301-5629(02)00566-5},
  volume       = {28},
  year         = {2002},
}