Corticosteroid action on choroid plexus: reduction in Na+-K+-ATPase activity, choline transport capacity, and rate of CSF formation
(1989) In Experimental Brain Research 77(3). p.605-610- Abstract
- Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated... (More)
- Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated influence of glucocorticoids on these functions of the choroid plexus seem to be important components in their therapeutic effect on intracranial hypertension. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104935
- author
- Lindvall-Axelsson, M ; Hedner, P and Owman, Christer LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Choroid plexus, Betamethasone, Transport capacity, Cerebrospinal fluid (CSF) production
- in
- Experimental Brain Research
- volume
- 77
- issue
- 3
- pages
- 605 - 610
- publisher
- Springer
- external identifiers
-
- pmid:2553468
- scopus:0024386087
- ISSN
- 0014-4819
- DOI
- 10.1007/BF00249613
- language
- English
- LU publication?
- yes
- id
- 08f2e329-124b-4078-b1b4-4e5f3e7768a1 (old id 1104935)
- date added to LUP
- 2016-04-01 12:27:41
- date last changed
- 2021-01-03 05:04:36
@article{08f2e329-124b-4078-b1b4-4e5f3e7768a1, abstract = {{Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated influence of glucocorticoids on these functions of the choroid plexus seem to be important components in their therapeutic effect on intracranial hypertension.}}, author = {{Lindvall-Axelsson, M and Hedner, P and Owman, Christer}}, issn = {{0014-4819}}, keywords = {{Choroid plexus; Betamethasone; Transport capacity; Cerebrospinal fluid (CSF) production}}, language = {{eng}}, number = {{3}}, pages = {{605--610}}, publisher = {{Springer}}, series = {{Experimental Brain Research}}, title = {{Corticosteroid action on choroid plexus: reduction in Na+-K+-ATPase activity, choline transport capacity, and rate of CSF formation}}, url = {{http://dx.doi.org/10.1007/BF00249613}}, doi = {{10.1007/BF00249613}}, volume = {{77}}, year = {{1989}}, }