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Corticosteroid action on choroid plexus: reduction in Na+-K+-ATPase activity, choline transport capacity, and rate of CSF formation

Lindvall-Axelsson, M; Hedner, P and Owman, Christer LU (1989) In Experimental Brain Research 77(3). p.605-610
Abstract
Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated... (More)
Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated influence of glucocorticoids on these functions of the choroid plexus seem to be important components in their therapeutic effect on intracranial hypertension. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Choroid plexus, Betamethasone, Transport capacity, Cerebrospinal fluid (CSF) production
in
Experimental Brain Research
volume
77
issue
3
pages
605 - 610
publisher
Springer
external identifiers
  • pmid:2553468
  • scopus:0024386087
ISSN
0014-4819
DOI
10.1007/BF00249613
language
English
LU publication?
yes
id
08f2e329-124b-4078-b1b4-4e5f3e7768a1 (old id 1104935)
date added to LUP
2008-08-07 09:09:04
date last changed
2017-01-01 05:09:47
@article{08f2e329-124b-4078-b1b4-4e5f3e7768a1,
  abstract     = {Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated influence of glucocorticoids on these functions of the choroid plexus seem to be important components in their therapeutic effect on intracranial hypertension.},
  author       = {Lindvall-Axelsson, M and Hedner, P and Owman, Christer},
  issn         = {0014-4819},
  keyword      = {Choroid plexus,Betamethasone,Transport capacity,Cerebrospinal fluid (CSF) production},
  language     = {eng},
  number       = {3},
  pages        = {605--610},
  publisher    = {Springer},
  series       = {Experimental Brain Research},
  title        = {Corticosteroid action on choroid plexus: reduction in Na+-K+-ATPase activity, choline transport capacity, and rate of CSF formation},
  url          = {http://dx.doi.org/10.1007/BF00249613},
  volume       = {77},
  year         = {1989},
}