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A generalized formulation of the 'incomplete-repair' model for cell survival and tissue response to fractionated low dose-rate irradiation

Nilsson, Per LU ; Thames, H D and Joiner, M C (1990) In International Journal of Radiation Biology 57(1). p.127-142
Abstract
A generalized equation for cell survival or tissue effects after fractionated low dose-rate irradiations, when there is incomplete repair between fractions and significant repair during fractions, is derived in terms of the h- and g-functions of the 'incomplete-repair' (IR) model. This model was developed originally from the concept of 'dose equivalent of incomplete repair', assuming that the repair of radiation damage is an exponential function of time and that the cell survival curve can be described adequately by the linear quadratic (LQ) formalism. The generalized incomplete-repair equation is shown to be equivalent to an expression derived by Dale et al. (1988) for analysis of tissue effects of fractionated irradiations at varying... (More)
A generalized equation for cell survival or tissue effects after fractionated low dose-rate irradiations, when there is incomplete repair between fractions and significant repair during fractions, is derived in terms of the h- and g-functions of the 'incomplete-repair' (IR) model. This model was developed originally from the concept of 'dose equivalent of incomplete repair', assuming that the repair of radiation damage is an exponential function of time and that the cell survival curve can be described adequately by the linear quadratic (LQ) formalism. The generalized incomplete-repair equation is shown to be equivalent to an expression derived by Dale et al. (1988) for analysis of tissue effects of fractionated irradiations at varying dose rates. The model is critically dependent on alpha/beta, repair half-time, treatment time and interfraction interval, and should therefore be regarded primarily as a tool for the analysis of fractionation and dose-rate effects in carefully designed radiobiological experiments, although it should also be useful in exploring, in a general way, the feasibility of clinical treatment protocols using fractionated low dose-rate treatments. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Radiation Biology
volume
57
issue
1
pages
127 - 142
publisher
Taylor & Francis
external identifiers
  • pmid:1967284
  • scopus:0025128605
ISSN
0955-3002
DOI
10.1080/09553009014550401
language
English
LU publication?
yes
id
f77328f7-8c46-4471-8271-dd412e00e09e (old id 1105122)
date added to LUP
2008-08-04 17:15:31
date last changed
2017-08-06 03:35:37
@article{f77328f7-8c46-4471-8271-dd412e00e09e,
  abstract     = {A generalized equation for cell survival or tissue effects after fractionated low dose-rate irradiations, when there is incomplete repair between fractions and significant repair during fractions, is derived in terms of the h- and g-functions of the 'incomplete-repair' (IR) model. This model was developed originally from the concept of 'dose equivalent of incomplete repair', assuming that the repair of radiation damage is an exponential function of time and that the cell survival curve can be described adequately by the linear quadratic (LQ) formalism. The generalized incomplete-repair equation is shown to be equivalent to an expression derived by Dale et al. (1988) for analysis of tissue effects of fractionated irradiations at varying dose rates. The model is critically dependent on alpha/beta, repair half-time, treatment time and interfraction interval, and should therefore be regarded primarily as a tool for the analysis of fractionation and dose-rate effects in carefully designed radiobiological experiments, although it should also be useful in exploring, in a general way, the feasibility of clinical treatment protocols using fractionated low dose-rate treatments.},
  author       = {Nilsson, Per and Thames, H D and Joiner, M C},
  issn         = {0955-3002},
  language     = {eng},
  number       = {1},
  pages        = {127--142},
  publisher    = {Taylor & Francis},
  series       = {International Journal of Radiation Biology},
  title        = {A generalized formulation of the 'incomplete-repair' model for cell survival and tissue response to fractionated low dose-rate irradiation},
  url          = {http://dx.doi.org/10.1080/09553009014550401},
  volume       = {57},
  year         = {1990},
}