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Actions of platelet-activating factor on isolated feline and human cerebral arteries

Uski, Tore LU and Reinstrup, Peter LU (1990) In Journal of Cerebral Blood Flow and Metabolism 10(3). p.428-431
Abstract
The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
10
issue
3
pages
428 - 431
publisher
Nature Publishing Group
external identifiers
  • pmid:2329129
  • scopus:0025228442
ISSN
1559-7016
language
English
LU publication?
yes
id
995303ba-8db7-456e-84e5-4179dd0c6770 (old id 1105159)
date added to LUP
2008-08-05 10:02:51
date last changed
2017-01-01 06:57:21
@article{995303ba-8db7-456e-84e5-4179dd0c6770,
  abstract     = {The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.},
  author       = {Uski, Tore and Reinstrup, Peter},
  issn         = {1559-7016},
  language     = {eng},
  number       = {3},
  pages        = {428--431},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Actions of platelet-activating factor on isolated feline and human cerebral arteries},
  volume       = {10},
  year         = {1990},
}