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Urinary excretion of the carboxy terminal domain of type IV collagen is associated with kidney size and function in IDDM

Torffvit, Ole LU ; Wieslander, Jörgen LU ; Forsberg, Lillemor; Hederström, Esbjörn and Agardh, Carl-David LU (1990) In The Journal of diabetic complications 4(4). p.166-169
Abstract
We evaluated whether urinary excretion of the carboxy terminal domain (NC1) of Type IV collagen is associated with glomerular filtration rate and kidney size in Type I (insulin-dependent) diabetes mellitus (IDDM). Urinary excretion rate of NC1, glomerular filtration rate (GFR), and kidney size were measured in 16 men with Type I diabetes. Their mean age was 33.3 +/- 6.1 years with a duration of diabetes of 14.9 +/- 3.7 years (mean +/- SD). The urinary excretion rate of NC1 was higher in the diabetic patients than in 18 healthy control subjects. Urinary excretion of NC1 was associated with both kidney size, parenchymal width, and GFR (r = 0.73, p = 0.001; r = 0.63, p = 0.009; r = 0.53, p = 0.04, respectively). The exact relationship between... (More)
We evaluated whether urinary excretion of the carboxy terminal domain (NC1) of Type IV collagen is associated with glomerular filtration rate and kidney size in Type I (insulin-dependent) diabetes mellitus (IDDM). Urinary excretion rate of NC1, glomerular filtration rate (GFR), and kidney size were measured in 16 men with Type I diabetes. Their mean age was 33.3 +/- 6.1 years with a duration of diabetes of 14.9 +/- 3.7 years (mean +/- SD). The urinary excretion rate of NC1 was higher in the diabetic patients than in 18 healthy control subjects. Urinary excretion of NC1 was associated with both kidney size, parenchymal width, and GFR (r = 0.73, p = 0.001; r = 0.63, p = 0.009; r = 0.53, p = 0.04, respectively). The exact relationship between these factors and basement membrane turnover/synthesis remains to be elucidated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of diabetic complications
volume
4
issue
4
pages
166 - 169
publisher
Elsevier
external identifiers
  • pmid:2151228
  • scopus:0025507748
ISSN
0891-6632
DOI
10.1016/0891-6632(90)90016-X
language
English
LU publication?
yes
id
31d2b57f-14f4-4f9e-8ef4-4f37f931bc71 (old id 1105161)
date added to LUP
2008-08-05 10:05:51
date last changed
2017-01-01 07:21:00
@article{31d2b57f-14f4-4f9e-8ef4-4f37f931bc71,
  abstract     = {We evaluated whether urinary excretion of the carboxy terminal domain (NC1) of Type IV collagen is associated with glomerular filtration rate and kidney size in Type I (insulin-dependent) diabetes mellitus (IDDM). Urinary excretion rate of NC1, glomerular filtration rate (GFR), and kidney size were measured in 16 men with Type I diabetes. Their mean age was 33.3 +/- 6.1 years with a duration of diabetes of 14.9 +/- 3.7 years (mean +/- SD). The urinary excretion rate of NC1 was higher in the diabetic patients than in 18 healthy control subjects. Urinary excretion of NC1 was associated with both kidney size, parenchymal width, and GFR (r = 0.73, p = 0.001; r = 0.63, p = 0.009; r = 0.53, p = 0.04, respectively). The exact relationship between these factors and basement membrane turnover/synthesis remains to be elucidated.},
  author       = {Torffvit, Ole and Wieslander, Jörgen and Forsberg, Lillemor and Hederström, Esbjörn and Agardh, Carl-David},
  issn         = {0891-6632},
  language     = {eng},
  number       = {4},
  pages        = {166--169},
  publisher    = {Elsevier},
  series       = {The Journal of diabetic complications},
  title        = {Urinary excretion of the carboxy terminal domain of type IV collagen is associated with kidney size and function in IDDM},
  url          = {http://dx.doi.org/10.1016/0891-6632(90)90016-X},
  volume       = {4},
  year         = {1990},
}