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The effect of unfractionated and low-molecular-weight heparin on the release of prostacyclin from the arterial wall

Brunkwall, J; Mätzsch, Thomas LU and Bergqvist, D (1990) In Blood Coagulation and Fibrinolysis 1(6). p.641-645
Abstract
Heparin is widely used as an antithrombotic agent, but one reported complication is thrombocytopenia associated with platelet aggregation. The mechanism is not fully clear but heparin interference in the prostaglandin production has been proposed. To investigate if heparin interacts with the production of prostacyclin from the vessel wall, and if low-molecular-weight heparin differs from unfractionated heparin in this respect, excised rabbit aortas were studied in a perfusion model. The vessels were perfused ex vivo for 5 x 15 min and in the last period arachidonic acid was added. Unfragmented heparin (500 IU/kg body weight) or low-molecular-weight heparin (LMWH) (500 antifactor Xa units/kg body weight) were given either 15 min before... (More)
Heparin is widely used as an antithrombotic agent, but one reported complication is thrombocytopenia associated with platelet aggregation. The mechanism is not fully clear but heparin interference in the prostaglandin production has been proposed. To investigate if heparin interacts with the production of prostacyclin from the vessel wall, and if low-molecular-weight heparin differs from unfractionated heparin in this respect, excised rabbit aortas were studied in a perfusion model. The vessels were perfused ex vivo for 5 x 15 min and in the last period arachidonic acid was added. Unfragmented heparin (500 IU/kg body weight) or low-molecular-weight heparin (LMWH) (500 antifactor Xa units/kg body weight) were given either 15 min before harvesting the vessels or added directly to the perfusate. The stable degradation product for prostacyclin, 6-keto-PGF1 alpha was not altered by addition of these agents. It is concluded that heparin and LMWH per se do not interact with the prostacyclin system in normal rabbit aortas in the doses studied. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Coagulation and Fibrinolysis
volume
1
issue
6
pages
641 - 645
publisher
Lippincott Williams and Wilkins
external identifiers
  • pmid:1966797
  • scopus:0025528942
ISSN
1473-5733
language
English
LU publication?
yes
id
93394b41-1c0d-48c6-a459-3aaac47d577f (old id 1105188)
date added to LUP
2008-08-05 10:28:58
date last changed
2017-01-01 04:37:53
@article{93394b41-1c0d-48c6-a459-3aaac47d577f,
  abstract     = {Heparin is widely used as an antithrombotic agent, but one reported complication is thrombocytopenia associated with platelet aggregation. The mechanism is not fully clear but heparin interference in the prostaglandin production has been proposed. To investigate if heparin interacts with the production of prostacyclin from the vessel wall, and if low-molecular-weight heparin differs from unfractionated heparin in this respect, excised rabbit aortas were studied in a perfusion model. The vessels were perfused ex vivo for 5 x 15 min and in the last period arachidonic acid was added. Unfragmented heparin (500 IU/kg body weight) or low-molecular-weight heparin (LMWH) (500 antifactor Xa units/kg body weight) were given either 15 min before harvesting the vessels or added directly to the perfusate. The stable degradation product for prostacyclin, 6-keto-PGF1 alpha was not altered by addition of these agents. It is concluded that heparin and LMWH per se do not interact with the prostacyclin system in normal rabbit aortas in the doses studied.},
  author       = {Brunkwall, J and Mätzsch, Thomas and Bergqvist, D},
  issn         = {1473-5733},
  language     = {eng},
  number       = {6},
  pages        = {641--645},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Blood Coagulation and Fibrinolysis},
  title        = {The effect of unfractionated and low-molecular-weight heparin on the release of prostacyclin from the arterial wall},
  volume       = {1},
  year         = {1990},
}