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Low molecular weight heparin compared with dextran as prophylaxis against thrombosis after total hip replacement

Mätzsch, Thomas LU ; Bergqvist, D; Fredin, H and Hedner, Ulla LU (1990) In Acta Chirurgica Scandinavica 156(6-7). p.445-450
Abstract
The effect of low molecular weight (LMW) heparin given once daily as prophylaxis against venous thrombosis was compared with that of dextran 70 in an open randomised trial of 100 patients undergoing elective total hip replacement. Four patients were withdrawn after randomisation and thus 96 were included in the final analysis. The development of thrombus was surveilled by the 125I fibrinogen test, and positive readings were verified by venography. Nine of 47 patients given LMW heparin developed thromboses (19%) compared with 18 of 49 given dextran (37%) (p = 0.09). Two further patients who received LMW heparin developed thromboses after leaving hospital (clinical signs became apparent on days 13 and 17, respectively), giving an overall... (More)
The effect of low molecular weight (LMW) heparin given once daily as prophylaxis against venous thrombosis was compared with that of dextran 70 in an open randomised trial of 100 patients undergoing elective total hip replacement. Four patients were withdrawn after randomisation and thus 96 were included in the final analysis. The development of thrombus was surveilled by the 125I fibrinogen test, and positive readings were verified by venography. Nine of 47 patients given LMW heparin developed thromboses (19%) compared with 18 of 49 given dextran (37%) (p = 0.09). Two further patients who received LMW heparin developed thromboses after leaving hospital (clinical signs became apparent on days 13 and 17, respectively), giving an overall rate of thrombosis in this group of 23%. Minor wound haematomas occurred in two of 47 in the LMW heparin group and three of 49 in the dextran group (4% and 6%, respectively), and blood loss, transfusion requirements, and reduction in postoperative haemoglobin concentration did not differ between the two groups. The studied LMW heparin given subcutaneously once a day was no less safe or effective than dextran in preventing thromboembolism after total hip replacement. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Chirurgica Scandinavica
volume
156
issue
6-7
pages
445 - 450
publisher
Almqvist & Wiksell
external identifiers
  • pmid:1695053
  • scopus:0025339692
ISSN
0001-5482
language
English
LU publication?
yes
id
99c7e769-9e17-4db0-92e8-7e408c5d18e7 (old id 1105196)
date added to LUP
2008-08-05 10:51:49
date last changed
2017-07-09 04:23:40
@article{99c7e769-9e17-4db0-92e8-7e408c5d18e7,
  abstract     = {The effect of low molecular weight (LMW) heparin given once daily as prophylaxis against venous thrombosis was compared with that of dextran 70 in an open randomised trial of 100 patients undergoing elective total hip replacement. Four patients were withdrawn after randomisation and thus 96 were included in the final analysis. The development of thrombus was surveilled by the 125I fibrinogen test, and positive readings were verified by venography. Nine of 47 patients given LMW heparin developed thromboses (19%) compared with 18 of 49 given dextran (37%) (p = 0.09). Two further patients who received LMW heparin developed thromboses after leaving hospital (clinical signs became apparent on days 13 and 17, respectively), giving an overall rate of thrombosis in this group of 23%. Minor wound haematomas occurred in two of 47 in the LMW heparin group and three of 49 in the dextran group (4% and 6%, respectively), and blood loss, transfusion requirements, and reduction in postoperative haemoglobin concentration did not differ between the two groups. The studied LMW heparin given subcutaneously once a day was no less safe or effective than dextran in preventing thromboembolism after total hip replacement.},
  author       = {Mätzsch, Thomas and Bergqvist, D and Fredin, H and Hedner, Ulla},
  issn         = {0001-5482},
  language     = {eng},
  number       = {6-7},
  pages        = {445--450},
  publisher    = {Almqvist & Wiksell},
  series       = {Acta Chirurgica Scandinavica},
  title        = {Low molecular weight heparin compared with dextran as prophylaxis against thrombosis after total hip replacement},
  volume       = {156},
  year         = {1990},
}