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MR imaging of the knee in acute rheumatoid arthritis: synovial uptake of gadolinium-DOTA

Björkengren, Ann G; Geborek, Pierre LU ; Rydholm, Urban LU ; Holtås, Stig LU and Petterson, Holger (1990) In American Journal of Roentgenology 155(2). p.329-332
Abstract
In patients with rheumatoid arthritis, the presence of acute synovial inflammation is an indication of the activity of the disease. It is an important finding because it often influences therapeutic decisions. However, acute synovitis may be difficult to detect by clinical examination, especially if a joint effusion also is present. As gadolinium tetra-azacyclododecane tetraacetic acid (Gd-DOTA) can be expected to accumulate in areas of acute inflammation, we studied the value of Gd-DOTA-enhanced MR to determine the presence of acute synovitis. Nine patients with current knee symptoms underwent MR examination of the knee. Short and long TR/TE MR images were obtained with a 0.3-T magnet before and immediately after IV administration of... (More)
In patients with rheumatoid arthritis, the presence of acute synovial inflammation is an indication of the activity of the disease. It is an important finding because it often influences therapeutic decisions. However, acute synovitis may be difficult to detect by clinical examination, especially if a joint effusion also is present. As gadolinium tetra-azacyclododecane tetraacetic acid (Gd-DOTA) can be expected to accumulate in areas of acute inflammation, we studied the value of Gd-DOTA-enhanced MR to determine the presence of acute synovitis. Nine patients with current knee symptoms underwent MR examination of the knee. Short and long TR/TE MR images were obtained with a 0.3-T magnet before and immediately after IV administration of Gd-DOTA. A 15-min delayed short TR/TE image also was obtained. Of eight patients with moderate to severe clinical evidence of acute synovitis, six had marked increase and two had moderate increase in signal intensity from synovial tissue on the short TR/TE image obtained immediately after administration of contrast material. In the ninth patient, who had minimal synovitis clinically, the signal from the synovium did not change after administration of contrast material. No difference was seen between the enhancement pattern on the immediate and the 15-min delayed images. These results suggest that Gd-DOTA is taken up by inflamed synovium and that Gd-DOTA-enhanced MR scans may be useful in detecting acute synovitis in patients with rheumatoid arthritis. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
American Journal of Roentgenology
volume
155
issue
2
pages
329 - 332
publisher
American Roentgen Ray Society
external identifiers
  • pmid:2115261
  • scopus:0025353827
ISSN
1546-3141
language
English
LU publication?
yes
id
92990d13-2aed-4c05-a002-caa38a706241 (old id 1105240)
alternative location
http://www.ajronline.org/cgi/reprint/155/2/329
date added to LUP
2008-08-05 11:22:14
date last changed
2017-08-06 03:51:07
@article{92990d13-2aed-4c05-a002-caa38a706241,
  abstract     = {In patients with rheumatoid arthritis, the presence of acute synovial inflammation is an indication of the activity of the disease. It is an important finding because it often influences therapeutic decisions. However, acute synovitis may be difficult to detect by clinical examination, especially if a joint effusion also is present. As gadolinium tetra-azacyclododecane tetraacetic acid (Gd-DOTA) can be expected to accumulate in areas of acute inflammation, we studied the value of Gd-DOTA-enhanced MR to determine the presence of acute synovitis. Nine patients with current knee symptoms underwent MR examination of the knee. Short and long TR/TE MR images were obtained with a 0.3-T magnet before and immediately after IV administration of Gd-DOTA. A 15-min delayed short TR/TE image also was obtained. Of eight patients with moderate to severe clinical evidence of acute synovitis, six had marked increase and two had moderate increase in signal intensity from synovial tissue on the short TR/TE image obtained immediately after administration of contrast material. In the ninth patient, who had minimal synovitis clinically, the signal from the synovium did not change after administration of contrast material. No difference was seen between the enhancement pattern on the immediate and the 15-min delayed images. These results suggest that Gd-DOTA is taken up by inflamed synovium and that Gd-DOTA-enhanced MR scans may be useful in detecting acute synovitis in patients with rheumatoid arthritis.},
  author       = {Björkengren, Ann G and Geborek, Pierre and Rydholm, Urban and Holtås, Stig and Petterson, Holger},
  issn         = {1546-3141},
  language     = {eng},
  number       = {2},
  pages        = {329--332},
  publisher    = {American Roentgen Ray Society},
  series       = {American Journal of Roentgenology},
  title        = {MR imaging of the knee in acute rheumatoid arthritis: synovial uptake of gadolinium-DOTA},
  volume       = {155},
  year         = {1990},
}