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MRI contrast media for the liver. Efficacy in conditions of acute biliary obstruction

Leander, Peter LU ; Golman, K; Klaveness, J; Holtz, E; Olsson, M and Leunbach, I (1990) In Investigative Radiology 25(10). p.1130-1134
Abstract
The authors investigated in a rat model the efficacy of magnetic resonance imaging (MRI) contrast media for evaluating the liver in conditions of acute biliary obstruction. Two liver-specific MRI contrast media, Cr-DEHIDA and Mn-DPDP, and the nonspecific agent Gd-DTPA were studied in normal rats and in rats whose bile ducts had been ligated before administration of the contrast medium. Images were made using a 2.4 T animal MRI system, and intensity enhancement of liver after contrast medium injection was calculated. Metal analyses of serum and liver tissue and T1 and T2 measurements on liver samples in vitro were performed. The differences in image intensity enhancement of liver between normal rats and rats with ligated bile ducts were not... (More)
The authors investigated in a rat model the efficacy of magnetic resonance imaging (MRI) contrast media for evaluating the liver in conditions of acute biliary obstruction. Two liver-specific MRI contrast media, Cr-DEHIDA and Mn-DPDP, and the nonspecific agent Gd-DTPA were studied in normal rats and in rats whose bile ducts had been ligated before administration of the contrast medium. Images were made using a 2.4 T animal MRI system, and intensity enhancement of liver after contrast medium injection was calculated. Metal analyses of serum and liver tissue and T1 and T2 measurements on liver samples in vitro were performed. The differences in image intensity enhancement of liver between normal rats and rats with ligated bile ducts were not significant for any of the three contrast media. Imaging with Mn-DPDP resulted in the highest intensity enhancement of the liver compared with Cr-DEHIDA and Gd-DTPA. Contrast media concentrations in liver tissue were not significantly different between normal rats and rats with ligated bile ducts; however, Cr-DEHIDA concentrations in serum were higher after bile duct ligation. In vitro measurements of liver tissue indicated unique relaxation properties for Mn-DPDP. This investigation indicates that the contrast media studied may be useful in situations where suspected liver pathology is complicated by acute biliary obstruction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Investigative Radiology
volume
25
issue
10
pages
1130 - 1134
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:2127772
ISSN
0020-9996
language
English
LU publication?
yes
id
f3fc9aea-d913-4b62-aed8-353d8102ede9 (old id 1105287)
date added to LUP
2008-08-05 12:15:04
date last changed
2016-04-15 20:39:17
@article{f3fc9aea-d913-4b62-aed8-353d8102ede9,
  abstract     = {The authors investigated in a rat model the efficacy of magnetic resonance imaging (MRI) contrast media for evaluating the liver in conditions of acute biliary obstruction. Two liver-specific MRI contrast media, Cr-DEHIDA and Mn-DPDP, and the nonspecific agent Gd-DTPA were studied in normal rats and in rats whose bile ducts had been ligated before administration of the contrast medium. Images were made using a 2.4 T animal MRI system, and intensity enhancement of liver after contrast medium injection was calculated. Metal analyses of serum and liver tissue and T1 and T2 measurements on liver samples in vitro were performed. The differences in image intensity enhancement of liver between normal rats and rats with ligated bile ducts were not significant for any of the three contrast media. Imaging with Mn-DPDP resulted in the highest intensity enhancement of the liver compared with Cr-DEHIDA and Gd-DTPA. Contrast media concentrations in liver tissue were not significantly different between normal rats and rats with ligated bile ducts; however, Cr-DEHIDA concentrations in serum were higher after bile duct ligation. In vitro measurements of liver tissue indicated unique relaxation properties for Mn-DPDP. This investigation indicates that the contrast media studied may be useful in situations where suspected liver pathology is complicated by acute biliary obstruction.},
  author       = {Leander, Peter and Golman, K and Klaveness, J and Holtz, E and Olsson, M and Leunbach, I},
  issn         = {0020-9996},
  language     = {eng},
  number       = {10},
  pages        = {1130--1134},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Investigative Radiology},
  title        = {MRI contrast media for the liver. Efficacy in conditions of acute biliary obstruction},
  volume       = {25},
  year         = {1990},
}