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Magnetic starch microspheres, efficacy and elimination. A new organ-specific contrast agent for magnetic resonance imaging

Fahlvik, A K; Holtz, E; Leander, Peter LU ; Schroder, U and Klaveness, J (1990) In Investigative Radiology 25(2). p.113-120
Abstract
A new particulate magnetic resonance (MR) contrast agent was prepared by controlled precipitation of iron oxide in an aqueous starch solution. The potential of the magnetic starch microspheres (MSM) as a hepatosplenic contrast enhancer was studied by MR spectroscopy and MR imaging. Intravascular administration of MSM to rodents showed an effective blood clearance and a tissue-specific localization of the substance. MSM doses in a range of 0.3-1.5 mg Fe/kg caused a 50% alteration in sensitive contrast parameters (ED50 doses) of liver and spleen. The contrast effect of MSM in liver and spleen was halved within 2 to 5 days. The approximated lethal MSM dose in mice was 150-200 mg Fe/kg. MSM is a tissue-specific MR contrast substance with high... (More)
A new particulate magnetic resonance (MR) contrast agent was prepared by controlled precipitation of iron oxide in an aqueous starch solution. The potential of the magnetic starch microspheres (MSM) as a hepatosplenic contrast enhancer was studied by MR spectroscopy and MR imaging. Intravascular administration of MSM to rodents showed an effective blood clearance and a tissue-specific localization of the substance. MSM doses in a range of 0.3-1.5 mg Fe/kg caused a 50% alteration in sensitive contrast parameters (ED50 doses) of liver and spleen. The contrast effect of MSM in liver and spleen was halved within 2 to 5 days. The approximated lethal MSM dose in mice was 150-200 mg Fe/kg. MSM is a tissue-specific MR contrast substance with high efficacy, rapid bioelimination, and low acute toxicity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Investigative Radiology
volume
25
issue
2
pages
113 - 120
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:2312246
  • scopus:0025122321
ISSN
0020-9996
language
English
LU publication?
yes
id
666ca7d4-3e98-4b76-971e-874173f344aa (old id 1105299)
date added to LUP
2008-08-05 12:17:23
date last changed
2017-01-01 04:39:58
@article{666ca7d4-3e98-4b76-971e-874173f344aa,
  abstract     = {A new particulate magnetic resonance (MR) contrast agent was prepared by controlled precipitation of iron oxide in an aqueous starch solution. The potential of the magnetic starch microspheres (MSM) as a hepatosplenic contrast enhancer was studied by MR spectroscopy and MR imaging. Intravascular administration of MSM to rodents showed an effective blood clearance and a tissue-specific localization of the substance. MSM doses in a range of 0.3-1.5 mg Fe/kg caused a 50% alteration in sensitive contrast parameters (ED50 doses) of liver and spleen. The contrast effect of MSM in liver and spleen was halved within 2 to 5 days. The approximated lethal MSM dose in mice was 150-200 mg Fe/kg. MSM is a tissue-specific MR contrast substance with high efficacy, rapid bioelimination, and low acute toxicity.},
  author       = {Fahlvik, A K and Holtz, E and Leander, Peter and Schroder, U and Klaveness, J},
  issn         = {0020-9996},
  language     = {eng},
  number       = {2},
  pages        = {113--120},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Investigative Radiology},
  title        = {Magnetic starch microspheres, efficacy and elimination. A new organ-specific contrast agent for magnetic resonance imaging},
  volume       = {25},
  year         = {1990},
}