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Histaminergic effects on the isolated rat ovarian artery during the estrous cycle

Schmidt, G; Kannisto, Päivi LU and Owman, Christer LU (1990) In Biology of Reproduction 42(5-6). p.762-768
Abstract
Histamine may play a role in many of the events occurring in the ovarian tissue and leading to ovulation. To elucidate the histaminergic influence on the ovarian vasculature, the mechanical response of the isolated rat ovarian artery to histamine and histamine agonists was investigated. Histamine relaxed the precontracted vessel segments in a concentration-dependent way, amounting to 82.7 +/- 4.3% of the papaverine-induced relaxation. This relaxant effect was counteracted by both the H1 antagonist, pyrilamine, and the H2 antagonist, cimetidine. That the effect of histamine was mediated by both histamine receptor subtypes was further confirmed by the relaxant effect produced in the presence of either of the H1-specific agonists,... (More)
Histamine may play a role in many of the events occurring in the ovarian tissue and leading to ovulation. To elucidate the histaminergic influence on the ovarian vasculature, the mechanical response of the isolated rat ovarian artery to histamine and histamine agonists was investigated. Histamine relaxed the precontracted vessel segments in a concentration-dependent way, amounting to 82.7 +/- 4.3% of the papaverine-induced relaxation. This relaxant effect was counteracted by both the H1 antagonist, pyrilamine, and the H2 antagonist, cimetidine. That the effect of histamine was mediated by both histamine receptor subtypes was further confirmed by the relaxant effect produced in the presence of either of the H1-specific agonists, 2-pyridylethylamine and 2-methylhistamine on the one hand, and the H2-specific agonists, impromidine and 4-methylhistamine on the other. The H1 receptor-induced relaxation was mediated via an effect on the endothelium, whereas the H2 receptor-mediated relaxation was mostly a direct effect on the smooth musculature in the vessel wall. No major differences in the mechanical response of the rat ovarian artery were seen during the different stages of the estrous cycle, although at late proestrus, just before ovulation, the maximum relaxation induced by histamine was particularly high, in spite of a low sensitivity of the receptors for the amine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biology of Reproduction
volume
42
issue
5-6
pages
762 - 768
publisher
Soc Study Reproduction
external identifiers
  • pmid:1974470
  • scopus:0025279278
ISSN
1529-7268
language
English
LU publication?
yes
id
44c54598-42e8-4fbd-8603-2271df4ec751 (old id 1105347)
alternative location
http://www.biolreprod.org/cgi/reprint/42/5/762
date added to LUP
2008-08-05 12:51:09
date last changed
2017-01-01 05:08:42
@article{44c54598-42e8-4fbd-8603-2271df4ec751,
  abstract     = {Histamine may play a role in many of the events occurring in the ovarian tissue and leading to ovulation. To elucidate the histaminergic influence on the ovarian vasculature, the mechanical response of the isolated rat ovarian artery to histamine and histamine agonists was investigated. Histamine relaxed the precontracted vessel segments in a concentration-dependent way, amounting to 82.7 +/- 4.3% of the papaverine-induced relaxation. This relaxant effect was counteracted by both the H1 antagonist, pyrilamine, and the H2 antagonist, cimetidine. That the effect of histamine was mediated by both histamine receptor subtypes was further confirmed by the relaxant effect produced in the presence of either of the H1-specific agonists, 2-pyridylethylamine and 2-methylhistamine on the one hand, and the H2-specific agonists, impromidine and 4-methylhistamine on the other. The H1 receptor-induced relaxation was mediated via an effect on the endothelium, whereas the H2 receptor-mediated relaxation was mostly a direct effect on the smooth musculature in the vessel wall. No major differences in the mechanical response of the rat ovarian artery were seen during the different stages of the estrous cycle, although at late proestrus, just before ovulation, the maximum relaxation induced by histamine was particularly high, in spite of a low sensitivity of the receptors for the amine.},
  author       = {Schmidt, G and Kannisto, Päivi and Owman, Christer},
  issn         = {1529-7268},
  language     = {eng},
  number       = {5-6},
  pages        = {762--768},
  publisher    = {Soc Study Reproduction},
  series       = {Biology of Reproduction},
  title        = {Histaminergic effects on the isolated rat ovarian artery during the estrous cycle},
  volume       = {42},
  year         = {1990},
}