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Indices of mineral metabolism in subjects with an impaired glucose tolerance

Lind, L; Lithell, H; Hvarfner, Andreas LU and Ljunghall, S (1990) In Experimental and Clinical Endocrinology 96(1). p.109-112
Abstract
An altered mineral metabolism has been described both in insulin dependent and non-insulin dependent diabetes mellitus. In order to investigate if a disturbed mineral homeostasis was an early feature in the development of diabetes, 52 middle-aged men who all had recently developed an impaired glucose tolerance (IGT) were compared to healthy control persons. The IGT subjects showed higher levels of serum calcium (2.38 +/- 0.081 mmol/l (SD) vs 2.35 +/- 0.065 in controls) but similar levels of plasma ionized calcium indicating an increased protein binding of serum calcium in IGT. Serum magnesium was significantly lower in the IGT subjects (0.79 +/- 0.060 mmol/l vs 0.85 +/- 0.065, p less than 0.001) while serum phosphate was unaltered. This... (More)
An altered mineral metabolism has been described both in insulin dependent and non-insulin dependent diabetes mellitus. In order to investigate if a disturbed mineral homeostasis was an early feature in the development of diabetes, 52 middle-aged men who all had recently developed an impaired glucose tolerance (IGT) were compared to healthy control persons. The IGT subjects showed higher levels of serum calcium (2.38 +/- 0.081 mmol/l (SD) vs 2.35 +/- 0.065 in controls) but similar levels of plasma ionized calcium indicating an increased protein binding of serum calcium in IGT. Serum magnesium was significantly lower in the IGT subjects (0.79 +/- 0.060 mmol/l vs 0.85 +/- 0.065, p less than 0.001) while serum phosphate was unaltered. This study demonstrates indices of an impaired mineral metabolism in IGT subjects similar in characteristics to what has previously been reported in manifest diabetes mellitus suggesting that an alteration of mineral homeostasis could be part of a primary event. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental and Clinical Endocrinology
volume
96
issue
1
pages
109 - 112
publisher
Johann Ambrosius Barth
external identifiers
  • pmid:2279519
  • scopus:0025103849
ISSN
0232-7384
language
English
LU publication?
yes
id
45977b00-d9b0-407b-8318-820e45564ba5 (old id 1105488)
date added to LUP
2008-08-05 16:25:44
date last changed
2017-01-01 07:08:09
@article{45977b00-d9b0-407b-8318-820e45564ba5,
  abstract     = {An altered mineral metabolism has been described both in insulin dependent and non-insulin dependent diabetes mellitus. In order to investigate if a disturbed mineral homeostasis was an early feature in the development of diabetes, 52 middle-aged men who all had recently developed an impaired glucose tolerance (IGT) were compared to healthy control persons. The IGT subjects showed higher levels of serum calcium (2.38 +/- 0.081 mmol/l (SD) vs 2.35 +/- 0.065 in controls) but similar levels of plasma ionized calcium indicating an increased protein binding of serum calcium in IGT. Serum magnesium was significantly lower in the IGT subjects (0.79 +/- 0.060 mmol/l vs 0.85 +/- 0.065, p less than 0.001) while serum phosphate was unaltered. This study demonstrates indices of an impaired mineral metabolism in IGT subjects similar in characteristics to what has previously been reported in manifest diabetes mellitus suggesting that an alteration of mineral homeostasis could be part of a primary event.},
  author       = {Lind, L and Lithell, H and Hvarfner, Andreas and Ljunghall, S},
  issn         = {0232-7384},
  language     = {eng},
  number       = {1},
  pages        = {109--112},
  publisher    = {Johann Ambrosius Barth},
  series       = {Experimental and Clinical Endocrinology},
  title        = {Indices of mineral metabolism in subjects with an impaired glucose tolerance},
  volume       = {96},
  year         = {1990},
}