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Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour

Wide-Swensson, Dag LU ; Ingemarsson, Ingemar LU ; Arulkumaran, S and Andersson, Karl-Erik LU (1990) In British Journal of Obstetrics and Gynaecology 97(10). p.945-949
Abstract
The effects of isradipine (a new calcium antagonist of the dihydropyridine type) on maternal blood pressure and heart rate, fetal heart rate, and uterine activity in labour were measured. Uterine activity was recorded by an intrauterine microtip transducer catheter connected to a fetal monitor. Isradipine was given as a slow injection in doses of 0.5 mg (10 women), 1 mg (11 women), and 1.5 mg (6 women). A reduction of systolic (6-16%) and diastolic (19-22%) blood pressure was seen, and concomitantly there was an increase in maternal (29-34%) and fetal (3-10%) heart rates. Reduction in uterine activity was not dose-related (maximum reduction 17%). Side effects (headache, palpitations) were minor and well tolerated. One women in the... (More)
The effects of isradipine (a new calcium antagonist of the dihydropyridine type) on maternal blood pressure and heart rate, fetal heart rate, and uterine activity in labour were measured. Uterine activity was recorded by an intrauterine microtip transducer catheter connected to a fetal monitor. Isradipine was given as a slow injection in doses of 0.5 mg (10 women), 1 mg (11 women), and 1.5 mg (6 women). A reduction of systolic (6-16%) and diastolic (19-22%) blood pressure was seen, and concomitantly there was an increase in maternal (29-34%) and fetal (3-10%) heart rates. Reduction in uterine activity was not dose-related (maximum reduction 17%). Side effects (headache, palpitations) were minor and well tolerated. One women in the high-dose group had a shortlasting episode of hypotension. The results suggest that isradipine given as a bolus dose decreases blood pressure in pregnant women with little effects on uterine activity and fetal heart rate. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Obstetrics and Gynaecology
volume
97
issue
10
pages
945 - 949
publisher
Wiley-Blackwell
external identifiers
  • pmid:2145969
  • scopus:0025059336
ISSN
1365-215X
DOI
10.1111/j.1471-0528.1990.tb02452.x
language
English
LU publication?
yes
id
4aa928fc-24ca-4951-b9d6-7f932209f1bd (old id 1105507)
date added to LUP
2008-08-05 16:51:40
date last changed
2017-08-20 03:42:27
@article{4aa928fc-24ca-4951-b9d6-7f932209f1bd,
  abstract     = {The effects of isradipine (a new calcium antagonist of the dihydropyridine type) on maternal blood pressure and heart rate, fetal heart rate, and uterine activity in labour were measured. Uterine activity was recorded by an intrauterine microtip transducer catheter connected to a fetal monitor. Isradipine was given as a slow injection in doses of 0.5 mg (10 women), 1 mg (11 women), and 1.5 mg (6 women). A reduction of systolic (6-16%) and diastolic (19-22%) blood pressure was seen, and concomitantly there was an increase in maternal (29-34%) and fetal (3-10%) heart rates. Reduction in uterine activity was not dose-related (maximum reduction 17%). Side effects (headache, palpitations) were minor and well tolerated. One women in the high-dose group had a shortlasting episode of hypotension. The results suggest that isradipine given as a bolus dose decreases blood pressure in pregnant women with little effects on uterine activity and fetal heart rate.},
  author       = {Wide-Swensson, Dag and Ingemarsson, Ingemar and Arulkumaran, S and Andersson, Karl-Erik},
  issn         = {1365-215X},
  language     = {eng},
  number       = {10},
  pages        = {945--949},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Obstetrics and Gynaecology},
  title        = {Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour},
  url          = {http://dx.doi.org/10.1111/j.1471-0528.1990.tb02452.x},
  volume       = {97},
  year         = {1990},
}