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Endobronchial biopsy positive sarcoidosis: relation to bronchoalveolar lavage and course of disease

Bjermer, Leif LU ; Thunell, M; Rosenhall, L and Stjernberg, N (1991) In Respiratory Medicine 85(3). p.229-234
Abstract
Sixty-two patients with newly diagnosed sarcoidosis were examined with fibreoptic bronchoscopy, endobronchial biopsies and bronchoalveolar lavage (BAL) were analysed. Epithelioid granulomatosis in endobronchial biopsies were found in 28 (45%) of the patients (BPOS). The patients in this BPOS group showed higher inflammatory activity in BAL fluid compared to those with negative biopsies (BNEG), with significant increases in lymphocyte and mast cell counts, and concentrations of procollagen III peptide and albumin. The patients were followed over a period of 2 years. The BPOS group tended to have a worse clinical course with more patients having a progressive disease and more patients requiring treatment with systemic steroids. We conclude... (More)
Sixty-two patients with newly diagnosed sarcoidosis were examined with fibreoptic bronchoscopy, endobronchial biopsies and bronchoalveolar lavage (BAL) were analysed. Epithelioid granulomatosis in endobronchial biopsies were found in 28 (45%) of the patients (BPOS). The patients in this BPOS group showed higher inflammatory activity in BAL fluid compared to those with negative biopsies (BNEG), with significant increases in lymphocyte and mast cell counts, and concentrations of procollagen III peptide and albumin. The patients were followed over a period of 2 years. The BPOS group tended to have a worse clinical course with more patients having a progressive disease and more patients requiring treatment with systemic steroids. We conclude that the findings of epithelioid granulomatosis in endobronchial biopsies may reflect a more intense and widespread inflammation in the lung. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
85
issue
3
pages
229 - 234
publisher
Elsevier
external identifiers
  • pmid:1882112
  • scopus:0025760216
ISSN
1532-3064
DOI
10.1016/S0954-6111(06)80085-5
language
English
LU publication?
no
id
5c8118e9-d854-4060-89dc-04c6d2541bfc (old id 1105689)
date added to LUP
2008-08-04 09:51:15
date last changed
2017-08-20 04:32:21
@article{5c8118e9-d854-4060-89dc-04c6d2541bfc,
  abstract     = {Sixty-two patients with newly diagnosed sarcoidosis were examined with fibreoptic bronchoscopy, endobronchial biopsies and bronchoalveolar lavage (BAL) were analysed. Epithelioid granulomatosis in endobronchial biopsies were found in 28 (45%) of the patients (BPOS). The patients in this BPOS group showed higher inflammatory activity in BAL fluid compared to those with negative biopsies (BNEG), with significant increases in lymphocyte and mast cell counts, and concentrations of procollagen III peptide and albumin. The patients were followed over a period of 2 years. The BPOS group tended to have a worse clinical course with more patients having a progressive disease and more patients requiring treatment with systemic steroids. We conclude that the findings of epithelioid granulomatosis in endobronchial biopsies may reflect a more intense and widespread inflammation in the lung.},
  author       = {Bjermer, Leif and Thunell, M and Rosenhall, L and Stjernberg, N},
  issn         = {1532-3064},
  language     = {eng},
  number       = {3},
  pages        = {229--234},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Endobronchial biopsy positive sarcoidosis: relation to bronchoalveolar lavage and course of disease},
  url          = {http://dx.doi.org/10.1016/S0954-6111(06)80085-5},
  volume       = {85},
  year         = {1991},
}