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Peripheral serotonergic markers in patients with suicidal behavior

Simonsson, Per LU ; Träskman Bendz, Lil LU ; Alling, Christer LU ; Oreland, Lars ; Regnell, Göran and Öhman, Rolf LU (1991) In European Neuropsychopharmacology 1(4). p.503-510
Abstract
Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced [32P]phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Suicide, Phosphatidylinositol 4, 5-bisphosphate, Serotonin, Serotonin2 receptors, Monoamine oxidase, Phospholipase C, Platelets, Blood
in
European Neuropsychopharmacology
volume
1
issue
4
pages
503 - 510
publisher
Elsevier
external identifiers
  • pmid:1668315
  • scopus:0026290475
ISSN
1873-7862
DOI
10.1016/0924-977X(91)90003-D
language
English
LU publication?
yes
id
e013ece9-fa25-4a41-af0a-93d23cc190ff (old id 1105809)
date added to LUP
2016-04-01 11:43:10
date last changed
2021-01-03 09:42:47
@article{e013ece9-fa25-4a41-af0a-93d23cc190ff,
  abstract     = {{Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced [32P]phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.}},
  author       = {{Simonsson, Per and Träskman Bendz, Lil and Alling, Christer and Oreland, Lars and Regnell, Göran and Öhman, Rolf}},
  issn         = {{1873-7862}},
  keywords     = {{Suicide; Phosphatidylinositol 4; 5-bisphosphate; Serotonin; Serotonin2 receptors; Monoamine oxidase; Phospholipase C; Platelets; Blood}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{503--510}},
  publisher    = {{Elsevier}},
  series       = {{European Neuropsychopharmacology}},
  title        = {{Peripheral serotonergic markers in patients with suicidal behavior}},
  url          = {{http://dx.doi.org/10.1016/0924-977X(91)90003-D}},
  doi          = {{10.1016/0924-977X(91)90003-D}},
  volume       = {{1}},
  year         = {{1991}},
}