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The association between plasma beta-hexosaminidase and its isoenzyme patterns and retinopathy in type 1 diabetes mellitus

Hultberg, Björn LU ; Isaksson, Anders LU ; Agardh, Elisabet LU and Agardh, Carl-David LU (1991) In Clinica Chimica Acta 196(2-3). p.177-183
Abstract
beta-Hexosaminidase and its isoenzyme patterns were investigated in plasma from patients with Type 1 diabetes mellitus. The patients were divided into three main groups matched for duration of diabetes: (a) proliferative retinopathy (b), progress of retinopathy within a two-year period (c) and with no background retinopathy. When all patients were compared to a reference group, a significant increase of plasma beta-hexosaminidase activity was found. Patients with proliferative retinopathy had significantly increased activity of plasma beta-hexosaminidase compared to the reference group but not compared to the other diabetic patients. The isoenzyme distribution was not different in any of the diabetic subgroups compared to the reference... (More)
beta-Hexosaminidase and its isoenzyme patterns were investigated in plasma from patients with Type 1 diabetes mellitus. The patients were divided into three main groups matched for duration of diabetes: (a) proliferative retinopathy (b), progress of retinopathy within a two-year period (c) and with no background retinopathy. When all patients were compared to a reference group, a significant increase of plasma beta-hexosaminidase activity was found. Patients with proliferative retinopathy had significantly increased activity of plasma beta-hexosaminidase compared to the reference group but not compared to the other diabetic patients. The isoenzyme distribution was not different in any of the diabetic subgroups compared to the reference group. It was also shown that various degrees of diabetic nephropathy did not influence total plasma Hex or the isoenzyme pattern. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinica Chimica Acta
volume
196
issue
2-3
pages
177 - 183
publisher
Elsevier
external identifiers
  • pmid:1827617
ISSN
0009-8981
language
English
LU publication?
yes
id
0881b901-c5c8-4df9-b994-850fb54feac5 (old id 1105842)
date added to LUP
2008-08-04 12:22:22
date last changed
2016-04-15 20:09:19
@article{0881b901-c5c8-4df9-b994-850fb54feac5,
  abstract     = {beta-Hexosaminidase and its isoenzyme patterns were investigated in plasma from patients with Type 1 diabetes mellitus. The patients were divided into three main groups matched for duration of diabetes: (a) proliferative retinopathy (b), progress of retinopathy within a two-year period (c) and with no background retinopathy. When all patients were compared to a reference group, a significant increase of plasma beta-hexosaminidase activity was found. Patients with proliferative retinopathy had significantly increased activity of plasma beta-hexosaminidase compared to the reference group but not compared to the other diabetic patients. The isoenzyme distribution was not different in any of the diabetic subgroups compared to the reference group. It was also shown that various degrees of diabetic nephropathy did not influence total plasma Hex or the isoenzyme pattern.},
  author       = {Hultberg, Björn and Isaksson, Anders and Agardh, Elisabet and Agardh, Carl-David},
  issn         = {0009-8981},
  language     = {eng},
  number       = {2-3},
  pages        = {177--183},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {The association between plasma beta-hexosaminidase and its isoenzyme patterns and retinopathy in type 1 diabetes mellitus},
  volume       = {196},
  year         = {1991},
}