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Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, B (2002) In Scandinavian Journal of Clinical & Laboratory Investigation 62(5). p.9-385
Abstract
In previous studies a high frequency of elevated plasma tHcy concentrations has been observed in psychogeriatric patients (40-50%), but the main cause of these increased concentrations could not be established with certainty. Impaired renal function could partly contribute to elevated plasma tHcy concentrations in psychogeriatric patients. Therefore, in the present study, cystatin C was used as a sensitive marker for glomerular filtration. A linear regression analysis including age, blood folate, serum cobalamin, serum cystatin C and serum creatinine showed that only serum creatinine (p<0.001) and blood folate (p<0.001) independently predicted plasma tHcy concentration. However, about 44% of the patients with elevated plasma tHcy... (More)
In previous studies a high frequency of elevated plasma tHcy concentrations has been observed in psychogeriatric patients (40-50%), but the main cause of these increased concentrations could not be established with certainty. Impaired renal function could partly contribute to elevated plasma tHcy concentrations in psychogeriatric patients. Therefore, in the present study, cystatin C was used as a sensitive marker for glomerular filtration. A linear regression analysis including age, blood folate, serum cobalamin, serum cystatin C and serum creatinine showed that only serum creatinine (p<0.001) and blood folate (p<0.001) independently predicted plasma tHcy concentration. However, about 44% of the patients with elevated plasma tHcy concentrations had signs of reduced glomerular filtration rate, as judged by increased serum cystatin C, whereas only about 13% of the patients with normal concentrations of plasma tHcy had signs of reduced glomerular filtration rate. This finding indicates that renal impairment may to some extent contribute to the elevated plasma tHcy concentration, even though serum cystatin C did not independently predict plasma tHcy concentration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
62
issue
5
pages
9 - 385
publisher
Informa Healthcare
external identifiers
  • pmid:12387585
  • wos:000178368100009
  • scopus:0036397339
ISSN
1502-7686
DOI
10.1080/00365510260296546
language
English
LU publication?
yes
id
7eba9377-0766-4ded-b5e0-64ba80356124 (old id 110586)
date added to LUP
2007-07-05 13:46:34
date last changed
2017-01-01 07:09:08
@article{7eba9377-0766-4ded-b5e0-64ba80356124,
  abstract     = {In previous studies a high frequency of elevated plasma tHcy concentrations has been observed in psychogeriatric patients (40-50%), but the main cause of these increased concentrations could not be established with certainty. Impaired renal function could partly contribute to elevated plasma tHcy concentrations in psychogeriatric patients. Therefore, in the present study, cystatin C was used as a sensitive marker for glomerular filtration. A linear regression analysis including age, blood folate, serum cobalamin, serum cystatin C and serum creatinine showed that only serum creatinine (p&lt;0.001) and blood folate (p&lt;0.001) independently predicted plasma tHcy concentration. However, about 44% of the patients with elevated plasma tHcy concentrations had signs of reduced glomerular filtration rate, as judged by increased serum cystatin C, whereas only about 13% of the patients with normal concentrations of plasma tHcy had signs of reduced glomerular filtration rate. This finding indicates that renal impairment may to some extent contribute to the elevated plasma tHcy concentration, even though serum cystatin C did not independently predict plasma tHcy concentration.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, B},
  issn         = {1502-7686},
  language     = {eng},
  number       = {5},
  pages        = {9--385},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients.},
  url          = {http://dx.doi.org/10.1080/00365510260296546},
  volume       = {62},
  year         = {2002},
}