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A study of exercise-induced microalbuminuria in type I (insulin-dependent) diabetes mellitus

Torffvit, Ole LU ; Castenfors, Jan and Agardh, Carl-David LU (1991) In Scandinavian Journal of Urology and Nephrology 25(1). p.39-43
Abstract
Microalbuminuria is thought to be an important prognostic factor in diabetes mellitus. To study the influence of changes in blood pressure on the development of microalbuminuria during exercise, two exercise tests were carried out. A total of 32 insulin dependent diabetic men whose age at onset was less than 30 years, mean duration of diabetes 14 years (range 7 to 21) and mean age 29 years (range 21 to 40), and who did not have albuminuria (N-labstix negative) were studied. The diabetic patients were compared with a total of 29 age-matched male control subjects. Urinary albumin excretion was measured during two exercise tests: at a standardised workload (150 W) for 30 min, and at a standardised heart rate for 25 min. The diabetic patients... (More)
Microalbuminuria is thought to be an important prognostic factor in diabetes mellitus. To study the influence of changes in blood pressure on the development of microalbuminuria during exercise, two exercise tests were carried out. A total of 32 insulin dependent diabetic men whose age at onset was less than 30 years, mean duration of diabetes 14 years (range 7 to 21) and mean age 29 years (range 21 to 40), and who did not have albuminuria (N-labstix negative) were studied. The diabetic patients were compared with a total of 29 age-matched male control subjects. Urinary albumin excretion was measured during two exercise tests: at a standardised workload (150 W) for 30 min, and at a standardised heart rate for 25 min. The diabetic patients had higher albumin excretion rates during both exercise tests compared with the control subjects. Blood pressure and heart rate during exercise were significantly higher in diabetic patients compared with control subjects in the standardised workload test. If the test was individualised to achieve the same standardised heart rate there was no significant difference in blood pressure between the diabetic patients and the control subjects. These results indicate that the diabetic kidneys were more sensitive than the healthy kidneys to similar degrees of haemodynamic stress induced by exercise. (Less)
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author
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type
Contribution to journal
publication status
published
subject
keywords
diabetic nephropathy, exercise, incipient nephropathy, systolic blood pressure, urinary albumin excretion rate, type I diabetes
in
Scandinavian Journal of Urology and Nephrology
volume
25
issue
1
pages
39 - 43
publisher
Taylor & Francis
external identifiers
  • pmid:2047771
  • scopus:0025971666
ISSN
0036-5599
DOI
10.3109/00365599109024527
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Medicine (Lund) (013230025)
id
4edd22e3-6e33-45b7-b7c5-3ce3907efbe2 (old id 1105898)
date added to LUP
2016-04-01 16:17:38
date last changed
2020-01-12 19:13:55
@article{4edd22e3-6e33-45b7-b7c5-3ce3907efbe2,
  abstract     = {Microalbuminuria is thought to be an important prognostic factor in diabetes mellitus. To study the influence of changes in blood pressure on the development of microalbuminuria during exercise, two exercise tests were carried out. A total of 32 insulin dependent diabetic men whose age at onset was less than 30 years, mean duration of diabetes 14 years (range 7 to 21) and mean age 29 years (range 21 to 40), and who did not have albuminuria (N-labstix negative) were studied. The diabetic patients were compared with a total of 29 age-matched male control subjects. Urinary albumin excretion was measured during two exercise tests: at a standardised workload (150 W) for 30 min, and at a standardised heart rate for 25 min. The diabetic patients had higher albumin excretion rates during both exercise tests compared with the control subjects. Blood pressure and heart rate during exercise were significantly higher in diabetic patients compared with control subjects in the standardised workload test. If the test was individualised to achieve the same standardised heart rate there was no significant difference in blood pressure between the diabetic patients and the control subjects. These results indicate that the diabetic kidneys were more sensitive than the healthy kidneys to similar degrees of haemodynamic stress induced by exercise.},
  author       = {Torffvit, Ole and Castenfors, Jan and Agardh, Carl-David},
  issn         = {0036-5599},
  language     = {eng},
  number       = {1},
  pages        = {39--43},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology},
  title        = {A study of exercise-induced microalbuminuria in type I (insulin-dependent) diabetes mellitus},
  url          = {http://dx.doi.org/10.3109/00365599109024527},
  doi          = {10.3109/00365599109024527},
  volume       = {25},
  year         = {1991},
}