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Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition.

Höglund, Mattias LU ; Gisselsson Nord, David LU ; Hansen, Gunnar B; Säll, Torbjörn LU ; Mitelman, Felix LU and Nilbert, Mef LU (2002) In Cancer Research 62(20). p.5939-5954
Abstract
More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well known. One reason why our understanding of the cytogenetic evolution is unclear is the high degree of karyotypic complexity seen in these tumors. To overcome some of these difficulties we have previously used several statistical methods that allow identification and interpretation of karyotypic pathways as well as establishment of a temporal order of appearance of the imbalances. These methods were applied on 531 colorectal... (More)
More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well known. One reason why our understanding of the cytogenetic evolution is unclear is the high degree of karyotypic complexity seen in these tumors. To overcome some of these difficulties we have previously used several statistical methods that allow identification and interpretation of karyotypic pathways as well as establishment of a temporal order of appearance of the imbalances. These methods were applied on 531 colorectal tumor karyotypes. By using a resampling strategy, 1p-, +7, 7q-, and +12p were identified as early events. Two major and two minor cytogenetic pathways were identified by means of principal component analysis. The two major pathways were initiated with 1p- and +7, and the minor pathways were initiated with +12p and 7q-. The +7/+12p tumors were found to be hyperdiploid, whereas those with 1p-/7q- were pseudodiploid. We also show that the adenoma-carcinoma transition in the 1p- pathway is strongly linked to karyoytypic evolution, whereas the +7 pathway is not, and that the cytogenetic pathways are separated at both early and late stages. (Less)
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Contribution to journal
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published
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Cancer Research
volume
62
issue
20
pages
5939 - 5954
publisher
American Association for Cancer Research Inc.
external identifiers
  • wos:000178693400048
  • pmid:12384560
  • scopus:0037108710
ISSN
1538-7445
language
English
LU publication?
yes
id
47ed3a4b-43ff-4fb0-9d00-682ee8cf546e (old id 110591)
alternative location
http://cancerres.aacrjournals.org/cgi/content/full/62/20/5939
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12384560&dopt=Abstract
date added to LUP
2007-07-07 08:12:50
date last changed
2017-05-21 04:14:46
@article{47ed3a4b-43ff-4fb0-9d00-682ee8cf546e,
  abstract     = {More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well known. One reason why our understanding of the cytogenetic evolution is unclear is the high degree of karyotypic complexity seen in these tumors. To overcome some of these difficulties we have previously used several statistical methods that allow identification and interpretation of karyotypic pathways as well as establishment of a temporal order of appearance of the imbalances. These methods were applied on 531 colorectal tumor karyotypes. By using a resampling strategy, 1p-, +7, 7q-, and +12p were identified as early events. Two major and two minor cytogenetic pathways were identified by means of principal component analysis. The two major pathways were initiated with 1p- and +7, and the minor pathways were initiated with +12p and 7q-. The +7/+12p tumors were found to be hyperdiploid, whereas those with 1p-/7q- were pseudodiploid. We also show that the adenoma-carcinoma transition in the 1p- pathway is strongly linked to karyoytypic evolution, whereas the +7 pathway is not, and that the cytogenetic pathways are separated at both early and late stages.},
  author       = {Höglund, Mattias and Gisselsson Nord, David and Hansen, Gunnar B and Säll, Torbjörn and Mitelman, Felix and Nilbert, Mef},
  issn         = {1538-7445},
  language     = {eng},
  number       = {20},
  pages        = {5939--5954},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition.},
  volume       = {62},
  year         = {2002},
}